具有抗炎活性的抗癌吡唑并嘧啶的活性成分鉴定与生物学评价。 - Suppr

Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity.

作者信息

Alcaro Stefano, Artese Anna, Botta Maurizio, Zizzari Alessandra T, Orallo Francisco, Ortuso Francesco, Schenone Silvia, Brullo Chiara, Yáñez Matilde

机构信息

Dipartimento di Scienze Farmacobiologiche, Università degli Studi "Magna Graecia" di Catanzaro, Italy.

出版信息

ChemMedChem. 2010 Aug 2;5(8):1242-6. doi: 10.1002/cmdc.201000165.

DOI:10.1002/cmdc.201000165

PMID:20564576

Abstract

摘要

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Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity.具有抗炎活性的抗癌吡唑并嘧啶的活性成分鉴定与生物学评价。

ChemMedChem. 2010 Aug 2;5(8):1242-6. doi: 10.1002/cmdc.201000165.

Synthesis and biological evaluation of novel pyrazole compounds.新型吡唑类化合物的合成与生物评价。

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Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.设计、合成及生物评价取代腙和吡唑衍生物作为选择性 COX-2 抑制剂：分子对接研究。

Bioorg Med Chem. 2011 Jun 1;19(11):3416-24. doi: 10.1016/j.bmc.2011.04.027. Epub 2011 Apr 22.

Synthesis and biological evaluation of some new 2-pyrazolines bearing benzene sulfonamide moiety as potential anti-inflammatory and anti-cancer agents.合成及一些新的 2-吡唑啉含有苯磺酰胺部分作为潜在的抗炎和抗癌剂的生物评价。

Eur J Med Chem. 2011 Dec;46(12):5763-8. doi: 10.1016/j.ejmech.2011.08.015. Epub 2011 Aug 16.

Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.合成并表征尼美舒利衍生物，作为环氧化酶-1/2 和 5-脂氧合酶的双重酶抑制剂。

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Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors.合成及生物评价 3-[4-(氨基/甲磺酰基)苯基]亚甲基-吲哚啉-2-酮衍生物作为新型 COX-1/2 和 5-LOX 抑制剂。

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7349-53. doi: 10.1016/j.bmcl.2010.10.056. Epub 2010 Oct 20.

Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of novel triarylpyrazoline derivatives as selective COX-2 inhibitors.新型三芳基吡唑啉衍生物作为选择性COX-2抑制剂的合成、环氧合酶抑制作用、抗炎评价及致溃疡倾向

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Synthesis of 2-methyl-3-indolylacetic derivatives as anti-inflammatory agents that inhibit preferentially cyclooxygenase 1 without gastric damage.作为优先抑制环氧化酶1且无胃损伤的抗炎剂的2-甲基-3-吲哚基乙酸衍生物的合成。

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Synthesis and biological evaluation of N-substituted-3,5-diphenyl-2-pyrazoline derivatives as cyclooxygenase (COX-2) inhibitors.N-取代-3,5-二苯基-2-吡唑啉衍生物的合成与生物评价作为环氧化酶（COX-2）抑制剂。

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Synthesis, anti-inflammatory activity and molecular docking studies of 2,5-diarylfuran amino acid derivatives.2,5-二芳基呋喃氨基酸衍生物的合成、抗炎活性及分子对接研究。

Eur J Med Chem. 2012 Jan;47(1):52-8. doi: 10.1016/j.ejmech.2011.10.018. Epub 2011 Oct 20.

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A facile, regioselective synthesis of novel 3-(N-phenylcarboxamide)pyrazolo[1,5-a]pyrimidine analogs in the presence of KHSO4 in aqueous media assisted by ultrasound and their antibacterial activities.在超声辅助下，于水介质中在硫酸氢钾存在的条件下简便、区域选择性地合成新型3-(N-苯基甲酰胺基)吡唑并[1,5-a]嘧啶类似物及其抗菌活性。

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Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity.

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