具有抗炎活性的抗癌吡唑并嘧啶的活性成分鉴定与生物学评价。 - Suppr

Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity.

作者信息

Alcaro Stefano, Artese Anna, Botta Maurizio, Zizzari Alessandra T, Orallo Francisco, Ortuso Francesco, Schenone Silvia, Brullo Chiara, Yáñez Matilde

机构信息

Dipartimento di Scienze Farmacobiologiche, Università degli Studi "Magna Graecia" di Catanzaro, Italy.

出版信息

ChemMedChem. 2010 Aug 2;5(8):1242-6. doi: 10.1002/cmdc.201000165.

DOI:10.1002/cmdc.201000165

PMID:20564576

Abstract

摘要

相似文献

Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity.

ChemMedChem. 2010 Aug 2;5(8):1242-6. doi: 10.1002/cmdc.201000165.

Synthesis and biological evaluation of novel pyrazole compounds.

Bioorg Med Chem. 2010 Aug 1;18(15):5685-96. doi: 10.1016/j.bmc.2010.06.018. Epub 2010 Jun 12.

Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.

Bioorg Med Chem. 2011 Jun 1;19(11):3416-24. doi: 10.1016/j.bmc.2011.04.027. Epub 2011 Apr 22.

Synthesis and biological evaluation of some new 2-pyrazolines bearing benzene sulfonamide moiety as potential anti-inflammatory and anti-cancer agents.

Eur J Med Chem. 2011 Dec;46(12):5763-8. doi: 10.1016/j.ejmech.2011.08.015. Epub 2011 Aug 16.

Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.

Bioorg Med Chem. 2011 Mar 15;19(6):2074-83. doi: 10.1016/j.bmc.2011.01.043. Epub 2011 Feb 1.

Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors.

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7349-53. doi: 10.1016/j.bmcl.2010.10.056. Epub 2010 Oct 20.

Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of novel triarylpyrazoline derivatives as selective COX-2 inhibitors.

Bioorg Med Chem Lett. 2015 Dec 15;25(24):5787-91. doi: 10.1016/j.bmcl.2015.10.047. Epub 2015 Oct 19.

Synthesis of 2-methyl-3-indolylacetic derivatives as anti-inflammatory agents that inhibit preferentially cyclooxygenase 1 without gastric damage.

J Med Chem. 2006 Dec 28;49(26):7774-80. doi: 10.1021/jm0608199.

Synthesis and biological evaluation of N-substituted-3,5-diphenyl-2-pyrazoline derivatives as cyclooxygenase (COX-2) inhibitors.

Eur J Med Chem. 2010 Dec;45(12):6135-8. doi: 10.1016/j.ejmech.2010.10.005. Epub 2010 Oct 25.

Synthesis, anti-inflammatory activity and molecular docking studies of 2,5-diarylfuran amino acid derivatives.

Eur J Med Chem. 2012 Jan;47(1):52-8. doi: 10.1016/j.ejmech.2011.10.018. Epub 2011 Oct 20.

引用本文的文献

Insights into the medicinal chemistry of heterocycles integrated with a pyrazolo[1,5-]pyrimidine scaffold.

RSC Med Chem. 2022 Sep 8;13(10):1150-1196. doi: 10.1039/d2md00192f. eCollection 2022 Oct 19.

A Novel Synthesis of Fused Uracils: Indenopyrimidopyridazines, Pyrimidopyridazines, and Pyrazolopyrimidines for Antimicrobial and Antitumor Evalution.

Molecules. 2016 Dec 14;21(12):1714. doi: 10.3390/molecules21121714.

Synthesis, Characterization, and Cytotoxicity of Some New 5-Aminopyrazole and Pyrazolo[1,5-a]pyrimidine Derivatives.

Sci Pharm. 2014 Oct 24;83(1):27-39. doi: 10.3797/scipharm.1409-14. Print 2015 Jan-Mar.

A facile, regioselective synthesis of novel 3-(N-phenylcarboxamide)pyrazolo[1,5-a]pyrimidine analogs in the presence of KHSO4 in aqueous media assisted by ultrasound and their antibacterial activities.

Mol Divers. 2016 May;20(2):379-90. doi: 10.1007/s11030-015-9639-6. Epub 2015 Oct 28.

A facile environment-friendly one-pot two-step regioselective synthetic strategy for 3,7-diarylpyrazolo[1,5-a]pyrimidines related to zaleplon and 3,6-diarylpyrazolo[1,5-a]pyrimidine-7-amines assisted by KHSO₄ in aqueous media.

Mol Divers. 2015 Nov;19(4):759-71. doi: 10.1007/s11030-015-9606-2. Epub 2015 May 28.

Synthesis, Structural Elucidation, and In Vitro Antitumor Activities of Some Pyrazolopyrimidines and Schiff Bases Derived from 5-Amino-3-(arylamino)-1H-pyrazole-4-carboxamides.

Sci Pharm. 2013 Apr-Jun;81(2):339-57. doi: 10.3797/scipharm.1211-07. Epub 2013 Jan 3.

18F-labeled pyrazolo[1,5-a]pyrimidine derivatives: synthesis from 2,4-dinitrobenzamide and tosylate precursors and comparative biological evaluation for tumor imaging with positron emission tomography.

Molecules. 2012 Mar 27;17(4):3774-93. doi: 10.3390/molecules17043774.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献