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[年轻男性动脉高血压初始阶段的内皮功能障碍及其与血管危险因素的关联]

[Endothelial dysfunction on initial stages of arterial hypertension among men of young age and it's connection with vascular risk factors].

作者信息

Shmorgun T S, Bovtiushko P V, Shakhnovich P G, Nikitin A E, Filippov A E, Zubenko A I

出版信息

Voen Med Zh. 2010 Apr;331(4):20-5.

Abstract

Frequency of display endothelial dysfunction, arising on the initial stages of development arterial hypertension is investigated, depending on vascular risk factors. The main group was made by 86 men with arterial hypertension I-II stage, group of the control--practically healthy 50 men. Vasomotor endothelial function defined on a degree of vasodilatation a humeral artery in reply to reactive hyperemia. Damage signs of endothelial monolayer estimated by quantity of free circulating endothelial blue blood cells. It is established, that the simultaneous combination of functional or structural vascular infringements among persons with normal blood pressure was registered in 3 times less often in comparison to patients with an arterial hypertension (p<0,01). At the main group at a simultaneous combination inadequate vasodilatation and endotheliaemia occurrence risk factors in 1,5 times is higher, than at their isolated display (p>0,05).

摘要

研究了在动脉高血压发展初期出现的内皮功能障碍的频率,该频率取决于血管危险因素。主要组由86名I-II期动脉高血压男性组成,对照组为50名实际健康的男性。通过肱动脉对反应性充血的血管舒张程度来定义血管运动内皮功能。通过游离循环内皮蓝血细胞数量评估内皮单层的损伤迹象。结果表明,与动脉高血压患者相比,血压正常者中功能性或结构性血管损伤同时存在的情况记录频率低3倍(p<0.01)。在主要组中,当血管舒张不足和内皮血症危险因素同时存在时,其发生风险比单独出现时高1.5倍(p>0.05)。

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