Motta C M, Hutchinson J S
Department of Agriculture, University of Aberdeen, UK.
J Reprod Fertil. 1991 May;92(1):65-73. doi: 10.1530/jrf.0.0920065.
Clomiphene citrate (2 mg/kg body wt) given on the day of mating can block or interrupt pregnancy in guinea-pigs. Corpus luteum function, uterine histology, implantation and embryo development were studied in clomiphene-treated and control animals on Days 5, 9 and 20 of pregnancy. Following treatment, only 25% of the females were regularly pregnant, presenting large and healthy foetuses. The other females examined showed either pregnancy with embryos undergoing resorption or no sign of pregnancy. In these females, corpus luteum size was reduced, progesterone concentrations were very low and the endometrial glands and the epithelium were often altered. It is concluded that clomiphene causes a reduction in fertility by altering the uterus and, by directly or indirectly inducing luteolysis, causes later pregnancy loss.
在交配当天给予柠檬酸氯米芬（2毫克/千克体重）可阻断或中断豚鼠的妊娠。在妊娠第5天、第9天和第20天，对接受氯米芬治疗的动物和对照动物的黄体功能、子宫组织学、着床和胚胎发育进行了研究。治疗后，只有25%的雌性动物正常妊娠，产出的胎儿大且健康。其他接受检查的雌性动物要么妊娠但胚胎正在吸收，要么没有妊娠迹象。在这些雌性动物中，黄体大小减小，孕酮浓度非常低，子宫内膜腺体和上皮细胞常发生改变。得出的结论是，氯米芬通过改变子宫并直接或间接诱导黄体溶解来降低生育力，导致后期妊娠丢失。
