Evans J J, Sin I L, Merrick A Y, Kelleher P R
J Reprod Fertil. 1981 May;62(1):205-11. doi: 10.1530/jrf.0.0620205.
Pregnant guinea-pigs were injected with oestrogen at different stages of gestation. After injections on Days 17 and 18 and on Days 25, 26, 32 and 33 peripheral maternal progesterone concentrations were lower than in control animals. Histology showed deleterious changes in the corpora lutea. After injections on Days 10 and 11 the maternal progesterone concentrations remained in the normal range for some time in 12 of 16 guinea-pigs and the corpora lutea appeared histologically normal. Oestrogen therefore affects the pregnancy differently at different stages of gestation.
在妊娠期的不同阶段给怀孕的豚鼠注射雌激素。在第17天和第18天以及第25天、26天、32天和33天注射后，母体外周孕酮浓度低于对照动物。组织学检查显示黄体有有害变化。在第10天和第11天注射后，16只豚鼠中有12只的母体孕酮浓度在一段时间内保持在正常范围内，且黄体在组织学上看起来正常。因此，雌激素在妊娠期的不同阶段对妊娠的影响不同。
