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[子宫间叶性及混合性肿瘤的预后因素]

[Prognostic factors of mesenchymal and mixed tumors of uterus].

作者信息

Spacek J, Laco J, Petera J, Jílek P, Krepinská E, Rezác A, Stipl S

机构信息

Porodnická a gynekologická klinika, LF a FN, Hradec Králové.

出版信息

Ceska Gynekol. 2009 Aug;74(4):292-7.

PMID:20564985
Abstract

OBJECTIVE

Analysis of clinical and histopathological prognostic factors with emphasis on carcinosarcomas, leiomyosarcomas and endometrial sarcomas of uterus.

SUBJECT

Review.

SETTING

Department of Obstetrics and Gynaecology, Medical Faculty Hradec Králové, Charles University, Prague; The Fingerland Department of Pathology, Medical Faculty Hradec Králové, Charles University, Prague; Department of Clinical Oncology, Medical Faculty Hradec Králové, Charles University, Prague; Department of Biological and Medical Sciences, Faculty of Pharmacy, Hradec Králové; Charles University, Prague.

SUBJECT AND METHOD

Discussion about our experience and current evidence.

CONCLUSION

Mesenchymal and mixed tumors of uterus are characterized by several prognostic factors as well. Except clinical prognostic variables, histopathological and molecular biological factors may play a role. The most important prognostic significance carry stage of disease, age and performance status of patient and sufficient therapy, especially surgery. In particular tumors some other prognostic factors are recognized. Except cases in really early stage of disease there is usually short interval between end of primary therapy and tumor recurrence. With the exception of endometrial stromal sarcoma, prognosis of these tumors remains very poor.

摘要

目的

分析临床和组织病理学预后因素,重点关注子宫癌肉瘤、平滑肌肉瘤和子宫内膜肉瘤。

主题

综述。

机构

布拉格查理大学赫拉德茨克拉洛韦医学院妇产科;布拉格查理大学赫拉德茨克拉洛韦医学院芬格兰德病理科;布拉格查理大学赫拉德茨克拉洛韦医学院临床肿瘤科;赫拉德茨克拉洛韦药学院生物与医学科学系;布拉格查理大学。

主题与方法

讨论我们的经验和当前证据。

结论

子宫间叶性和混合性肿瘤也有若干预后因素。除临床预后变量外,组织病理学和分子生物学因素可能起作用。最重要的预后意义在于疾病分期、患者年龄和体能状态以及充分的治疗,尤其是手术。在某些特定肿瘤中还认识到其他预后因素。除疾病真正处于早期的病例外,初次治疗结束至肿瘤复发的间隔通常较短。除子宫内膜间质肉瘤外,这些肿瘤的预后仍然很差。

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