Sando Zacharie, Fouelifack Florent Ymele, Fouogue Jovanny Tsuala, Fouedjio Jeanne Hortence, Anoudem Chimene Etonga, Nangue Charlette
Yaounde Gyneco-Obstetric and Pediatric Hospital, Cameroon ; Faculty of Medicine and Biomedical Sciences of the University of Yaounde 1, Cameroon.
Yaoundé Central Hospital, Cameroon.
Pan Afr Med J. 2013 Dec 19;16:145. doi: 10.11604/pamj.2013.16.145.3497. eCollection 2013.
Carcinosarcoma of the uterus is a rare tumor representing 2-4% of uterine malignancies. Its prognosis is poor with a 5 years survival rate of 10-30%. We report a first documented case of carcinosarcoma occurring in a 62 years old woman who presented with postmenopausal vaginal bleeding for one year. The preoperative biopsy of endometrium revealed a leiomyosarcoma. Total body Computerized Tomography (CT) Scan revealed a mass limited to the uterus without other abnormalities. We carried out a total abdominal hysterectomy with bilateral salpingo-oophorectomy. Post operative histology of the specimen found a carcinosarcoma. The patient underwent a course of radiotherapy and a total body CT Scan done eight months later revealed no signs of recurrence or metastasis. Clinicopathological aspects, treatment options and prognosis of this aggressive neoplasm are reviewed. We recommend practitioners to be aware of this lesion for an early diagnosis and appropriate treatment.
子宫癌肉瘤是一种罕见的肿瘤，占子宫恶性肿瘤的2%-4%。其预后较差，5年生存率为10%-30%。我们报告首例有记录的子宫癌肉瘤病例，患者为一名62岁女性，绝经后阴道出血1年。子宫内膜术前活检显示为平滑肌肉瘤。全身计算机断层扫描（CT）显示肿块局限于子宫，无其他异常。我们进行了全腹子宫切除术及双侧输卵管卵巢切除术。术后标本组织学检查发现为癌肉瘤。患者接受了一个疗程的放疗，8个月后进行的全身CT扫描显示无复发或转移迹象。本文回顾了这种侵袭性肿瘤的临床病理特征、治疗选择及预后。我们建议医生了解这种病变以便早期诊断和进行适当治疗。
