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用于牙周疾病诊断和治疗的唾液检测。

Salivary testing for periodontal disease diagnosis and treatment.

作者信息

Nabors Thomas W, McGlennen Ronald C, Thompson Doug

机构信息

OralDNA Labs.

出版信息

Dent Today. 2010 Jun;29(6):53-4, 56, 58-60; quiz 61.

PMID:20565019
Abstract

For more than 50 years, clinicians have relied primarily on the same visual and mechanical assessment methods to diagnose and classify periodontal disease. Clinical signs are simply a measurement of the past damage of a disease process. While clinical presentation and probing depths are indicators that the disease exists, these alone cannot determine the types and quantities of the responsible pathogens. Likewise, clinical signs alone cannot determine if therapy has achieved the goal of suppression of the etiological agent(s). Genetic presymptomatic testing complements bacterial DNA testing by providing insight into the patient's genetic predisposition to periodontal disease before symptoms appear, or when disease is already present. DNA-PCR testing of saliva can help the clinician provide an earlier and more specific diagnosis of disease based on causation. Treatment planning is also enhanced, as therapy can be appropriately modified based on both clinical and biological inflammatory factors. Finally, patient communication and case acceptance can be more readily achieved because the test reports elicit a persuasive "seeing is believing" attitude when reviewing test results with patients. Through the use of accurate periodontal charting, medical and dental risk assessments, and other diagnostic screening tests such as OralNA's MyPerioPath and MyPerioID PST tests, highly personalized periodontal therapy can be developed and carried out by the general practitioner. There has never been a better time to become more aware, and keep tighter control, of the periodontal status of one's patient base. Many patients are asking dentists about the connection between periodontal health and general health, While it currently would not be appropriate to suggest a causative relationship, there is abundant ongoing research that suggests a correlative relationship between periodontal disease and other whole-body ailments. Many patients have refused periodontal care or denied the importance of maintaining their periodontal health. The use of tools such as the OralDNA test report can assist in achieving patient acceptance of needed treatment and cooperation with the clinician to improve their periodontal health. The contents of the report and the visual presentation demonstrate that many patients have an active infection that can be stabilized if treated. Patients also provide more information about other factors that may contribute to their periodontal condition. Further, the OralDNA report enhances dentist-physician communication and a team approach to patient care.

摘要

五十多年来,临床医生主要依靠相同的视觉和机械评估方法来诊断和分类牙周疾病。临床体征仅仅是对疾病过程过去损害的一种衡量。虽然临床表现和探诊深度是疾病存在的指标,但仅凭这些无法确定致病病原体的类型和数量。同样,仅凭临床体征也无法确定治疗是否达到了抑制病原体的目标。基因症状前检测通过在症状出现之前或疾病已经存在时,深入了解患者对牙周疾病的遗传易感性,对细菌DNA检测起到补充作用。唾液的DNA-PCR检测可以帮助临床医生基于病因做出更早、更具体的疾病诊断。治疗计划也得到了加强,因为可以根据临床和生物炎症因素对治疗进行适当调整。最后,患者沟通和病例接受度更容易实现,因为在与患者回顾检测结果时,检测报告会引发一种有说服力的“眼见为实”的态度。通过使用准确的牙周记录、医学和牙科风险评估以及其他诊断筛查测试,如OralNA的MyPerioPath和MyPerioID PST测试,全科医生可以制定并实施高度个性化的牙周治疗。现在是时候更加关注并更严格地控制患者群体的牙周状况了。许多患者向牙医询问牙周健康与整体健康之间的联系,虽然目前不宜暗示因果关系,但有大量正在进行的研究表明牙周疾病与其他全身疾病之间存在关联。许多患者拒绝接受牙周护理或否认保持牙周健康的重要性。使用OralDNA检测报告等工具可以帮助患者接受所需的治疗,并与临床医生合作改善他们的牙周健康。报告的内容和视觉呈现表明,许多患者存在活跃感染,如果得到治疗是可以稳定病情的。患者还提供了更多关于可能导致其牙周状况的其他因素的信息。此外,OralDNA报告加强了牙医与医生之间的沟通以及患者护理的团队协作方式。

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Br Dent J. 2014 Nov;217(10):567-73. doi: 10.1038/sj.bdj.2014.1005.
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Salivary biomarkers in the diagnosis of periodontal diseases.唾液生物标志物在牙周疾病诊断中的应用
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