金纳米粒子包覆的聚（3-羟基丁酸酯）颗粒的体外自组装，表现出等离子体诱导的热光增强。

In vitro self-assembly of gold nanoparticle-coated poly(3-hydroxybutyrate) granules exhibiting plasmon-induced thermo-optical enhancements.

出版信息

ACS Appl Mater Interfaces. 2010 Jul;2(7):1804-10. doi: 10.1021/am100306m.

PMID:20565131

Abstract

Polyhydroxyalkanoate (PHA) synthase attached to gold nanoparticles (AuNP) produce poly(3-hydroxybutyrate) (PHB) upon the addition of 3-hydroxybutyrate-CoA, and then coalesce to form micrometer-sized AuNP-coated PHB granules. These AuNP-coated PHB granules are potential theranostic agents that have enhanced imaging capabilities and are capable of heating upon near-infrared laser irradiation. The AuNP-coated PHB exhibited 11-fold enhancement in surface-enhanced Raman scattering over particles prior polymerization. Stained AuNP-coated PHB exhibited a 6-fold enhancement in fluorescence intensity as well as a 1.3-fold decrease in photobleaching rate compared to PHB granules alone. The granules were also shown to emit heat when illuminated at 808 nm with a 3.9-fold increase in heating rate compared to particles alone.

摘要

多羟基烷酸酯 (PHA) 合酶附着在金纳米粒子 (AuNP) 上，在添加 3-羟基丁酰辅酶 A 后会产生聚 (3-羟基丁酸酯) (PHB)，然后聚合并形成微米级的 AuNP 涂层 PHB 颗粒。这些 AuNP 涂层 PHB 颗粒是潜在的治疗诊断剂，具有增强的成像能力，并能在近红外激光照射下加热。AuNP 涂层 PHB 的表面增强拉曼散射比聚合前的颗粒增强了 11 倍。与单独的 PHB 颗粒相比，染色的 AuNP 涂层 PHB 的荧光强度增强了 6 倍，光漂白率降低了 1.3 倍。当用 808nm 的光照射时，颗粒也显示出发热现象，与单独的颗粒相比，加热速率增加了 3.9 倍。