聚羟基脂肪酸酯（PHA）及其基纳米颗粒的合成、表征与应用
The Synthesis, Characterization and Applications of Polyhydroxyalkanoates (PHAs) and PHA-Based Nanoparticles.
作者信息
Samrot Antony V, Samanvitha Sree K, Shobana N, Renitta Emilin R, Senthilkumar P, Kumar Suresh S, Abirami S, Dhiva S, Bavanilatha M, Prakash P, Saigeetha S, Shree Krithika S, Thirumurugan R
机构信息
School of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jalan SP2, Bandar Saujana Putra, Jenjarom 42610, Selangor, Malaysia.
Department of Biotechnology, Shanmugha Arts, Science, Technology & Research Academy, Thanjavur 613401, Tamil Nadu, India.
出版信息
Polymers (Basel). 2021 Sep 27;13(19):3302. doi: 10.3390/polym13193302.
Polyhydroxyalkanoates (PHAs) are storage granules found in bacteria that are essentially hydroxy fatty acid polyesters. PHA molecules appear in variety of structures, and amongst all types of PHAs, polyhydroxybutyrate (PHB) is used in versatile fields as it is a biodegradable, biocompatible, and ecologically safe thermoplastic. The unique physicochemical characteristics of these PHAs have made them applicable in nanotechnology, tissue engineering, and other biomedical applications. In this review, the optimization, extraction, and characterization of PHAs are described. Their production and application in nanotechnology are also portrayed in this review, and the precise and various production methods of PHA-based nanoparticles, such as emulsion solvent diffusion, nanoprecipitation, and dialysis are discussed. The characterization techniques such as UV-Vis, FTIR, SEM, Zeta Potential, and XRD are also elaborated.
聚羟基脂肪酸酯（PHA）是细菌中发现的储存颗粒，本质上是羟基脂肪酸聚酯。PHA分子呈现出多种结构，在所有类型的PHA中，聚羟基丁酸酯（PHB）因其是一种可生物降解、生物相容且生态安全的热塑性塑料而被广泛应用于各个领域。这些PHA独特的物理化学特性使其适用于纳米技术、组织工程和其他生物医学应用。在本综述中，描述了PHA的优化、提取和表征。还介绍了它们在纳米技术中的生产和应用，并讨论了基于PHA的纳米颗粒的精确且多样的生产方法，如乳液溶剂扩散法、纳米沉淀法和透析法。还阐述了紫外可见光谱（UV-Vis）、傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）、zeta电位和X射线衍射（XRD）等表征技术。
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