Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.
J Infect Dis. 2010 Aug 15;202(3):386-91. doi: 10.1086/653705.
Casp8p41 is a protein fragment generated by cleavage of procaspase 8 by human immunodeficiency virus (HIV) protease. We measured Casp8p41 content in memory CD4 T cells and analyzed the association of Casp8p41 content with CD4 T cell count, cross-sectionally and longitudinally. Casp8p41 content was inversely correlated with CD4 T cell count, and change in Casp8p41 content was associated with absolute CD4 T cell count with change over time. Casp8p41 change was a better predictor of CD4 T cell count change than activated CD8 T cell percentage or viral load and was comparable to bacterial 16s DNA levels. This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection.
Casp8p41 是由人类免疫缺陷病毒 (HIV) 蛋白酶切割 procaspase 8 产生的蛋白片段。我们测量了记忆性 CD4 T 细胞中的 Casp8p41 含量，并分析了 Casp8p41 含量与 CD4 T 细胞计数的横断面和纵向关联。Casp8p41 含量与 CD4 T 细胞计数呈负相关，Casp8p41 含量的变化与绝对 CD4 T 细胞计数随时间的变化相关。与激活的 CD8 T 细胞百分比或病毒载量相比，Casp8p41 的变化能更好地预测 CD4 T 细胞计数的变化，与细菌 16sDNA 水平相当。这表明 Casp8p41 是 HIV 感染期间 CD4 T 细胞死亡的相关介质。
