Division of Cardiovascular and Diabetes Research, Section on Mechanisms of Thrombosis, Leeds Institute for Genetics Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds, UK.
Part Fibre Toxicol. 2010 Jun 16;7:17. doi: 10.1186/1743-8977-7-17.
Exposure to urban particulate matter has been associated with an increased risk of cardiovascular disease and thrombosis. We studied the effects of transient exposure to diesel particles on fibrin clot structure of 16 healthy individuals (age 21-44). The subjects were randomly exposed to diesel exhaust and filtered air on two separate occasions. Blood samples were collected before exposure, and 2 and 6 hours after exposure. There were no significant changes on clot permeability, maximum turbidity, lag time, fibre diameter, fibre density and fibrinogen level between samples taken after diesel exhaust exposure and samples taken after filtered air exposure. These data show that there are no prothrombotic changes in fibrin clot structure in young, healthy individuals exposed to diesel exhaust.
暴露于城市颗粒物与心血管疾病和血栓形成的风险增加有关。我们研究了短暂接触柴油颗粒对 16 名健康个体（年龄 21-44 岁）纤维蛋白凝块结构的影响。受试者在两次单独的情况下随机暴露于柴油废气和过滤空气中。在暴露前、暴露后 2 小时和 6 小时采集血样。暴露于柴油废气后的样本与暴露于过滤空气后的样本相比，在血栓通透性、最大浑浊度、滞后时间、纤维直径、纤维密度和纤维蛋白原水平方面均无显著变化。这些数据表明，年轻健康个体暴露于柴油废气中时，纤维蛋白凝块结构没有促血栓形成变化。
