Siyami Ersek Cardiovascular and Thoracic Surgery Center, Training and Research Hospital, Cardiology Department, Istanbul, Turkey.
Angiology. 2010 Nov;61(8):751-5. doi: 10.1177/0003319710373747. Epub 2010 Jun 21.
Consecutive patients (n = 235) with coronary ischemia were studied; 69 patients (29%) had diabetes. An oral glucose tolerance test (OGTT) was administered to the 166 patients without diabetes; 76 (46%) had normal glucose tolerance (group I = NGT), 68 (41%) had impaired glucose tolerance ([IGT] group II = IGT), and 22 (13%) had diabetic glucose tolerance (DGT). The DGT patients were added to the known diabetics forming (Group III; n = 91). Multivessel disease was significantly more prevalent in group III; 30 patients (43%) in group I, 32 patients (51%) in group II, and 57 patients (69%) in group III (P = .002). Gensini scores were 43.20 ± 24.92 in group I, 54.22 ± 42.61 in group II, and 60.59 ± 38.21 in group III. (P = .037) The severity of coronary artery disease is related to abnormal glucose tolerance. Patients with IGT could be neglected in terms of interventions focused to improve risk factors.
连续 235 例有冠状动脉缺血的患者接受了研究；其中 69 例（29%）有糖尿病。166 例无糖尿病患者进行了口服葡萄糖耐量试验（OGTT）；其中 76 例（46%）有正常葡萄糖耐量（I 组=NGT），68 例（41%）有糖耐量受损（IGT 组 II = IGT），22 例（13%）有糖尿病糖耐量（DGT）。将 DGT 患者添加到已知的糖尿病患者中，形成（III 组；n = 91）。多血管疾病在 III 组中更为常见；I 组中有 30 例（43%），II 组中有 32 例（51%），III 组中有 57 例（69%）（P =.002）。I 组的 Gensini 评分是 43.20 ± 24.92，II 组是 54.22 ± 42.61，III 组是 60.59 ± 38.21（P =.037）。冠状动脉疾病的严重程度与异常的葡萄糖耐量有关。对于以改善危险因素为重点的干预措施，IGT 患者可能会被忽视。
