Gardner Kevin H, Davis Mark D P, Richardson Donna M, Pittelkow Mark R
Department of Dermatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Arch Dermatol. 2010 Aug;146(8):886-90. doi: 10.1001/archdermatol.2010.114. Epub 2010 Jun 21.
Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), a common preservative in some brands of moist toilet paper (baby wipes and moist towelettes), has been reported to be a cause of allergic contact dermatitis. However, few cases have been reported in the United States.
We report the cases of 4 adult patients with severe perianal and perineal allergic contact dermatitis seen at our institution during a 6-month period. With patch testing, we identified allergy to MCI/MI, and we determined that all 4 patients were using moist toilet paper. The dermatitis resolved after use of the moist toilet paper was discontinued.
This study highlights that the MCI/MI in moist toilet paper can be a cause of perianal and perineal allergic contact dermatitis.
甲基氯异噻唑啉酮/甲基异噻唑啉酮（MCI/MI）是某些品牌湿厕纸（婴儿湿巾和湿纸巾）中常用的防腐剂，据报道它是过敏性接触性皮炎的一个病因。然而，在美国报道的病例很少。
我们报告了在6个月期间我们机构收治的4例患有严重肛周和会阴过敏性接触性皮炎的成年患者的病例。通过斑贴试验，我们确定患者对MCI/MI过敏，并且我们确定所有4例患者都在使用湿厕纸。停用湿厕纸后，皮炎消退。
本研究强调湿厕纸中的MCI/MI可能是肛周和会阴过敏性接触性皮炎的一个病因。
