Department of Pathology, Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA.
Int J Gynecol Pathol. 2010 Jul;29(4):315-20. doi: 10.1097/PGP.0b013e3181c7c977.
Fourteen steroid cell tumors (SCTs) of the ovary were studied by immunohistochemistry including inhibin, calretinin, CD99, Melan A, androgen receptor, and AE1/3. Twelve tumors were primary and 2 were recurrent. The primary tumors included 5 stromal luteomas (SL), 5 SCTs, not otherwise specified, and 2 Leydig cell tumors, 1 of the hilar type and 1 of the nonhilar type. All tumors were classified according to the predominant cell type. Six tumors were eosinophilic cell type, 3 clear-cell type, and 5 were mixed eosinophilic-clear-cell type. Inhibin, calretinin, and CD99 were positive in all 14 tumors. Twelve of 14 tumors (86%) were positive for Melan A and 9 of 14 (64%) for androgen receptor. AE 1/3 immunopositivity was found in 5 of 14 tumors (36%). Immunohistochemistry helps in the distinction between SCTs of the ovary and other primary or metastatic ovarian neoplasms with eosinophilic and clear-cell histology. In addition, immunohistochemistry can confirm the presence of recurrent SCT, if no sufficient clinical history is provided. As some SCTs can be positive for epithelial markers and histologically similar epithelial tumors can be positive for sex cord stromal markers, the use of multiple immunohistochemical stains is recommended.
我们通过免疫组织化学研究了 14 例卵巢类固醇细胞瘤（SCT），其中包括抑制素、钙视网膜蛋白、CD99、Melan A、雄激素受体和 AE1/3。12 例为原发性肿瘤，2 例为复发性肿瘤。原发性肿瘤包括 5 例间质黄体瘤（SL）、5 例未特指的 SCT 和 2 例睾丸间质细胞瘤，其中 1 例为门细胞瘤，1 例为非门细胞瘤。所有肿瘤均根据主要细胞类型进行分类。6 例为嗜酸性细胞型，3 例为透明细胞型，5 例为嗜酸性-透明细胞混合型。14 例肿瘤中均有抑制素、钙视网膜蛋白和 CD99 阳性。14 例肿瘤中有 12 例（86%）对 Melan A 阳性，9 例（64%）对雄激素受体阳性。AE1/3 免疫组化阳性见于 5 例（36%）肿瘤。免疫组织化学有助于鉴别卵巢 SCT 与其他具有嗜酸性和透明细胞组织学特征的原发性或转移性卵巢肿瘤。此外，如果没有提供足够的临床病史，则可以通过免疫组织化学来确认复发性 SCT 的存在。由于一些 SCT 可能对上皮标记物呈阳性，而组织学上相似的上皮肿瘤可能对性索间质标记物呈阳性，因此建议使用多种免疫组织化学染色。
