Tan Eek Chaw, Khong Chit Chong, Bhutia Kazila
Division of Obstetrics & Gynaecology, KK Women's and Children's Hospital, Singapore.
Case Rep Obstet Gynecol. 2019 Jul 25;2019:4375839. doi: 10.1155/2019/4375839. eCollection 2019.
Steroid cell tumour is a rare sex cord-stromal tumor of the ovary. It may produce steroids and is associated with testosterone secretion which causes symptoms like hair loss, hirsutism, and oligomenorrhea/amenorrhea due to hormonal activity and virilizing properties of tumor. In this article, we reported a 27-year-old woman who presented with hirsutism, hoarseness of voice, scalp hair fall, and amenorrhea for 8 years. Clinical and diagnostic evaluation revealed a left adnexal mass and elevated serum levels of testosterone and she was diagnosed as having a Sertoli Leydig cell tumour of ovary. She underwent left salpingooophorectomy and both histopathological examination and immunohistochemistry confirmed the diagnosis. Her serum testosterone levels normalized 3 days after the surgery and her menses resumed spontaneously a few months after the operation. In addition, we reviewed the literature on the epidemiology, clinical presentations, imaging and histological findings, and the treatment options on this disease.
类固醇细胞瘤是一种罕见的卵巢性索间质肿瘤。它可产生类固醇，并与睾酮分泌有关，由于肿瘤的激素活性和男性化特性，可导致脱发、多毛症以及月经过少/闭经等症状。在本文中，我们报告了一名27岁女性，她出现多毛症、声音嘶哑、头皮脱发和闭经8年。临床和诊断评估显示左附件区有肿块，血清睾酮水平升高，她被诊断为卵巢支持-间质细胞瘤。她接受了左侧输卵管卵巢切除术，组织病理学检查和免疫组化均证实了诊断。术后3天她的血清睾酮水平恢复正常，术后几个月月经自然恢复。此外，我们还回顾了关于该疾病的流行病学、临床表现、影像学和组织学发现以及治疗选择的文献。
