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挪威产科肛门括约肌损伤危险因素的变化趋势。

Trends in risk factors for obstetric anal sphincter injuries in Norway.

机构信息

From the Institute of Clinical Medicine, University of Bergen; the Department of Obstetrics and Gynecology, Haukeland University Hospital; the Medical Birth Registry of Norway, Norwegian Institute of Public Health; and the Locus for Registry Based Epidemiology, Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway.

出版信息

Obstet Gynecol. 2010 Jul;116(1):25-34. doi: 10.1097/AOG.0b013e3181e2f50b.

Abstract

OBJECTIVE

To investigate risk factors for obstetric anal sphincter injuries in a large population-based data set, and to assess to what extent changes in these risk factors could account for trends in obstetric anal sphincter injuries.

METHODS

This is a population-based cohort study on data from the Medical Birth Registry of Norway between 1967 and 2004, including all vaginal singleton deliveries of vertex-presenting fetuses weighing 500 g or more. Women with their first birth before 1967 and births with previous obstetric anal sphincter injuries were excluded, leaving 1,673,442 births for study. The outcome variable was third- and fourth-degree obstetric anal sphincter injuries. The associations of obstetric anal sphincter injuries with possible risk factors were estimated by odds ratios (ORs) obtained by logistic regression.

RESULTS

The occurrence of obstetric anal sphincter injuries increased from 0.5% in 1967 to 4.1% in 2004. After adjusting for demographic and other risk factors, as well as possible confounders, the increase of obstetric anal sphincter injuries persisted, although reduced (unadjusted OR 7.1; 95% confidence interval [CI] 6.8-7.4; adjusted OR 5.6; 95% CI 5.3-5.9). Obstetric anal sphincter injuries were significantly associated with maternal age 30 years or older, vaginal birth order of one, previous cesarean delivery, instrumental delivery, episiotomy, type 1 diabetes, gestational diabetes, induction of labor by prostaglandin, size of maternity unit, birth weight 3,500 g or more, head circumference 35 cm or more, and African or Asian country of birth.

CONCLUSION

Risk of obstetric anal sphincter injuries considerably increased in Norway in 1967 to 2004. Changes in the risk factors studied could only partially explain this increase.

LEVEL OF EVIDENCE

II.

摘要

目的

在一个大型基于人群的数据集中,调查产科肛门括约肌损伤的危险因素,并评估这些危险因素的变化在多大程度上可以解释产科肛门括约肌损伤的趋势。

方法

这是一项基于人群的队列研究,数据来自挪威医学出生登记处 1967 年至 2004 年的数据,包括所有体重 500 克或以上的头位胎儿的阴道单胎分娩。排除 1967 年前首次分娩和先前有产科肛门括约肌损伤的分娩,共 1673442 例分娩用于研究。结局变量为三度和四度产科肛门括约肌损伤。通过逻辑回归获得的优势比(OR)来估计产科肛门括约肌损伤与可能的危险因素之间的关联。

结果

产科肛门括约肌损伤的发生率从 1967 年的 0.5%增加到 2004 年的 4.1%。在调整了人口统计学和其他危险因素以及可能的混杂因素后,尽管有所减少,但产科肛门括约肌损伤的增加仍然存在(未经调整的 OR 7.1;95%置信区间 [CI] 6.8-7.4;调整后的 OR 5.6;95% CI 5.3-5.9)。产科肛门括约肌损伤与母亲年龄 30 岁或以上、阴道分娩次数 1 次、先前剖宫产、器械分娩、会阴切开术、1 型糖尿病、妊娠期糖尿病、前列腺素诱导分娩、分娩单位规模、出生体重 3500 克或以上、头围 35 厘米或以上以及非洲或亚洲出生国家显著相关。

结论

1967 年至 2004 年,挪威产科肛门括约肌损伤的风险显著增加。研究中危险因素的变化只能部分解释这种增加。

证据水平

II。

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