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慢性肾脏病的神经精神并发症。

Neuropsychiatric complications of chronic kidney disease.

机构信息

Toronto General Hospital, 200 Elizabeth Street, 8N-825, Toronto, ON M5G 2C4, Canada.

出版信息

Nat Rev Nephrol. 2010 Aug;6(8):471-9. doi: 10.1038/nrneph.2010.83. Epub 2010 Jun 22.

DOI:10.1038/nrneph.2010.83
PMID:20567247
Abstract

Evidence is emerging that cognitive impairment, delirium and depression are very common in patients with renal disease. All of these conditions are associated with prolonged hospitalization and an increased risk of mortality. A good understanding of these conditions is key to their prevention, early intervention and management. This Review summarizes the clinical features of various forms of cognitive dysfunction that occur in individuals with renal disease and describes the evidence for the high burden of disease in such patients.

摘要

越来越多的证据表明,认知障碍、谵妄和抑郁在肾病患者中非常常见。所有这些情况都与住院时间延长和死亡率增加有关。对这些情况的充分了解是预防、早期干预和管理的关键。这篇综述总结了肾病患者中出现的各种形式认知功能障碍的临床特征,并描述了此类患者疾病负担高的证据。

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本文引用的文献

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A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease.阿法达贝泊汀治疗2型糖尿病和慢性肾病的一项试验。
N Engl J Med. 2009 Nov 19;361(21):2019-32. doi: 10.1056/NEJMoa0907845. Epub 2009 Oct 30.
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CKD associates with cognitive decline.慢性肾脏病与认知功能下降相关。
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Depression and nonadherence are closely related in dialysis patients.
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慢性肾脏病认知障碍模式的一种新方法。
Nephrol Dial Transplant. 2024 Apr 26;39(5):848-859. doi: 10.1093/ndt/gfad244.
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Pathogenesis of Chronic Kidney Disease Is Closely Bound up with Alzheimer's Disease, Especially via the Renin-Angiotensin System.慢性肾脏病的发病机制与阿尔茨海默病密切相关,尤其是通过肾素-血管紧张素系统。
J Clin Med. 2023 Feb 12;12(4):1459. doi: 10.3390/jcm12041459.
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Utility of continuous performance test (MOXO-CPT) in children with pre-dialysis chronic kidney disease, dialysis and kidney transplantation.连续性能测试(MOXO-CPT)在预透析慢性肾脏病、透析和肾移植患儿中的应用。
J Nephrol. 2022 Sep;35(7):1873-1883. doi: 10.1007/s40620-022-01382-1. Epub 2022 Jul 23.
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The Influence of Serum Uric Acid on the Brain and Cognitive Dysfunction.血清尿酸对大脑及认知功能障碍的影响
Front Psychiatry. 2022 Apr 22;13:828476. doi: 10.3389/fpsyt.2022.828476. eCollection 2022.
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The Emerging Evidence for a Protective Role of Fucoidan from in Chronic Kidney Disease-Triggered Cognitive Dysfunction.褐藻糖胶在慢性肾脏病引发的认知功能障碍中的保护作用的新证据。
Mar Drugs. 2022 Apr 7;20(4):258. doi: 10.3390/md20040258.
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Effects of uremic toxins on hippocampal synaptic transmission: implication for neurodegeneration in chronic kidney disease.尿毒症毒素对海马突触传递的影响:对慢性肾脏病神经退行性变的意义。
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