Department of Plastic Surgery, The Cleveland Clinic, Cleveland, Ohio.
Semin Plast Surg. 2007 Nov;21(4):205-12. doi: 10.1055/s-2007-991190.
Composite tissue allotransplantation has been recently introduced as a potential clinical treatment for complex reconstructive procedures including traumatic injuries, cancer ablative surgeries, or extensive tissue loss secondary to burns. Composite tissue allografts (CTAs) consist of heterogeneous tissues including skin, fat, muscle, nerves, lymph nodes, bone, cartilage, ligaments, and bone marrow with different antigenicities. Thus, composite tissue structure is considered to be more immunogenic than solid organ transplants. In this article, we present the experimental applications of CTA transplantation. To study the mechanisms of CTA acceptance and rejection, different experimental models, strategies, and different immunosuppressive protocols were used.
复合组织同种异体移植最近被引入作为一种潜在的临床治疗方法，用于复杂的重建手术，包括创伤性损伤、癌症消融手术，或广泛的组织损失继发于烧伤。复合组织移植物（CTA）由多种组织组成，包括皮肤、脂肪、肌肉、神经、淋巴结、骨骼、软骨、韧带和骨髓，具有不同的抗原性。因此，复合组织结构被认为比实体器官移植更具免疫原性。本文介绍了 CTA 移植的实验应用。为了研究 CTA 接受和排斥的机制，使用了不同的实验模型、策略和不同的免疫抑制方案。
