Cleveland, Ohio; and Istanbul and Diyarbakır, Turkey From the Department of Plastic Surgery, Cleveland Clinic; Department of Plastic and Reconstructive Surgery and Burn Unit, Gülhane Military Medical Academy and Medical Faculty, Haydarpasa Training Hospital; and Dicle University Department of Plastic and Reconstructive Surgery.
Plast Reconstr Surg. 2009 Dec;124(6 Suppl):e327-e339. doi: 10.1097/PRS.0b013e3181bf8413.
Recently, composite tissue allotransplantation was introduced as a potential clinical treatment for complex reconstructive procedures, including tumor ablative operations, traumatic injuries, and extensive tissue loss secondary to burns. Composite tissue allotransplantations consist of heterogeneous tissues including skin, fat, muscle, nerves, lymph nodes, bone, cartilage, ligaments, and bone marrow, all presenting with different antigenicity. Thus, composite tissue allotransplantations are considered to elicit a stronger response compared with solid organ transplants. This article outlines different experimental models and current clinical applications of composite tissue allotransplantation.
最近，复合组织同种异体移植被引入作为复杂重建手术的一种潜在临床治疗方法，包括肿瘤消融手术、创伤损伤以及烧伤引起的广泛组织损失。复合组织同种异体移植由多种组织组成，包括皮肤、脂肪、肌肉、神经、淋巴结、骨骼、软骨、韧带和骨髓，所有这些组织都具有不同的抗原性。因此，与实体器官移植相比，复合组织同种异体移植被认为会引起更强的反应。本文概述了复合组织同种异体移植的不同实验模型和当前临床应用。
