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Tribbles homologue 3 (TRIB3) and the insulin-resistance genes in type 2 diabetes.

作者信息

Beguinot F

机构信息

Department of Cellular and Molecular Biology and Pathology, University of Naples Federico II, via Sergio Pansini, 5, Naples, Italy.

出版信息

Diabetologia. 2010 Sep;53(9):1831-4. doi: 10.1007/s00125-010-1824-7. Epub 2010 Jun 22.

DOI:10.1007/s00125-010-1824-7
PMID:20567803
Abstract
摘要

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Biochem Soc Trans. 2015 Oct;43(5):1122-6. doi: 10.1042/BST20150124.
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Double tribble: two TRIB3 variants, insulin, Akt, and eNOS.双三阴性乳腺癌:两种TRIB3变体、胰岛素、蛋白激酶B和内皮型一氧化氮合酶。
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Fatty acids differentially regulate insulin resistance through endoplasm reticulum stress-mediated induction of tribbles homologue 3: a potential link between dietary fat composition and the pathophysiological outcomes of obesity.脂肪酸通过内质网应激介导的 tribbles 同源物 3 的诱导差异调节胰岛素抵抗:膳食脂肪组成与肥胖的病理生理结果之间的潜在联系。
Diabetologia. 2013 Sep;56(9):2078-87. doi: 10.1007/s00125-013-2973-2. Epub 2013 Jul 3.
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Curr Protein Pept Sci. 2017;18(8):819-842. doi: 10.2174/1389203718666170406124547.
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The emerging role of TRIB3 as a gene affecting human insulin resistance and related clinical outcomes.TRIB3作为影响人类胰岛素抵抗及相关临床结局的基因所起的新作用。
Acta Diabetol. 2009 Jun;46(2):79-84. doi: 10.1007/s00592-008-0087-y. Epub 2009 Jan 13.
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TRIB3 R84 variant is associated with impaired insulin-mediated nitric oxide production in human endothelial cells.TRIB3 R84变异体与人类内皮细胞中胰岛素介导的一氧化氮生成受损有关。
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TRIB3 Is Highly Expressed in the Adipose Tissue of Obese Patients and Is Associated With Insulin Resistance.TRIB3 在肥胖患者的脂肪组织中高表达,并与胰岛素抵抗相关。
J Clin Endocrinol Metab. 2022 Feb 17;107(3):e1057-e1073. doi: 10.1210/clinem/dgab780.
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Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans.胰岛素抵抗肥胖人群肝脏中 TRIB3 基因表达异常。
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Sitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in the Zucker Diabetic Fatty rat - focus on amelioration of metabolic profile and tissue cytoprotective properties.西他列汀可预防 Zucker 糖尿病肥胖大鼠内、外分泌胰腺损伤的恶化 - 重点改善代谢特征和组织细胞保护特性。
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本文引用的文献

1
Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans.胰岛素抵抗肥胖人群肝脏中 TRIB3 基因表达异常。
Diabetologia. 2010 Sep;53(9):1971-5. doi: 10.1007/s00125-010-1772-2. Epub 2010 May 13.
2
Epigenetics: a molecular link between environmental factors and type 2 diabetes.表观遗传学:环境因素与2型糖尿病之间的分子联系。
Diabetes. 2009 Dec;58(12):2718-25. doi: 10.2337/db09-1003.
3
Insulin signaling regulating genes: effect on T2DM and cardiovascular risk.胰岛素信号调节基因:对 T2DM 和心血管风险的影响。
Early life factors and type 2 diabetes mellitus.
早期生活因素与 2 型糖尿病。
J Diabetes Res. 2013;2013:485082. doi: 10.1155/2013/485082. Epub 2013 Dec 16.
Nat Rev Endocrinol. 2009 Dec;5(12):682-93. doi: 10.1038/nrendo.2009.215.
4
Signal transduction mechanism of TRB3 in rats with non-alcoholic fatty liver disease.非酒精性脂肪性肝病大鼠中TRB3的信号转导机制
World J Gastroenterol. 2009 May 21;15(19):2329-35. doi: 10.3748/wjg.15.2329.
5
TRIB3 functional Q84R polymorphism is a risk factor for metabolic syndrome and carotid atherosclerosis.TRIB3功能性Q84R多态性是代谢综合征和颈动脉粥样硬化的一个危险因素。
Diabetes Care. 2009 Jul;32(7):1311-3. doi: 10.2337/dc09-0061. Epub 2009 Apr 23.
6
Genetic dissection of type 2 diabetes.2型糖尿病的基因剖析
Mol Cell Endocrinol. 2009 Jan 15;297(1-2):10-7. doi: 10.1016/j.mce.2008.10.002. Epub 2008 Oct 19.
7
The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes.TRIB3基因Q84R多态性与早发型2型糖尿病风险
J Clin Endocrinol Metab. 2009 Jan;94(1):190-6. doi: 10.1210/jc.2008-1365. Epub 2008 Nov 4.
8
Role of the ENPP1 K121Q polymorphism in glucose homeostasis.ENPP1 K121Q基因多态性在葡萄糖稳态中的作用。
Diabetes. 2008 Dec;57(12):3360-4. doi: 10.2337/db07-1830. Epub 2008 Sep 5.
9
Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?新发现的基因位点凸显β细胞功能障碍是2型糖尿病的关键病因:胰岛素抵抗基因何在?
Diabetologia. 2008 Jul;51(7):1100-10. doi: 10.1007/s00125-008-1025-9. Epub 2008 May 27.
10
Hepatic insulin resistance induced by prenatal alcohol exposure is associated with reduced PTEN and TRB3 acetylation in adult rat offspring.产前酒精暴露诱导的肝脏胰岛素抵抗与成年大鼠子代中PTEN和TRB3乙酰化水平降低有关。
Am J Physiol Regul Integr Comp Physiol. 2008 Jun;294(6):R1797-806. doi: 10.1152/ajpregu.00804.2007. Epub 2008 Apr 2.