Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
Mov Disord. 2010 Jul 30;25(10):1496-8. doi: 10.1002/mds.23155.
Unilateral pallidotomy has been effectively used to treat parkinsonism and reduce levodopa induced dyskinesia (LID). We sought to determine the long-term effects of pallidotomy on LID in 10 patients who had initial benefit from pallidotomy but went on to require DBS surgery for symptom progression. The Dyskinesia Rating Scale (DRS) was used to rate and quantify LID in a blinded fashion. Though sample size was small, there was a trend towards a reduction in LID lasting up to 12 years suggesting that posteroventral pallidotomy may provide sustained benefit in reducing LID.
单侧苍白球切开术已被有效地用于治疗帕金森病并减少左旋多巴诱导的运动障碍（LID）。我们试图确定苍白球切开术对 10 名最初受益于苍白球切开术但随后因症状进展需要 DBS 手术的患者的 LID 的长期影响。使用运动障碍评分量表（DRS）以盲法对 LID 进行评分和量化。尽管样本量较小，但 LID 持续减少的趋势持续了 12 年，这表明后腹侧苍白球切开术可能在减少 LID 方面提供持续的益处。
