Department of Periodontology, School of Dentistry, University of Damascus, Damascus, Syria.
J Periodontol. 2010 Nov;81(11):1547-54. doi: 10.1902/jop.2010.100173. Epub 2010 Jun 22.
Several recent studies have indicated that total antioxidant capacity (TAOC) of plasma seems to be compromised in chronic periodontitis (ChP). The aim of this study is to investigate plasma TAOC in patients with ChP and to assess the effects of vitamin C as an adjunct to non-surgical periodontal treatment.
The study population consisted of 60 subjects: 30 diagnosed with ChP and 30 matched controls. Furthermore, patients from the ChP group were randomly allocated into ChP1 (15 patients received non-surgical treatment with adjunctive dose of vitamin C) and ChP2 (15 patients received non-surgical periodontal treatment alone). Plasma TAOC levels were measured by an ABTS assay at baseline and 1 month post-therapy.
Plasma TAOC levels were significantly lower in ChP patients than controls (P <0.001). The periodontal therapy resulted in increasing plasma TAOC and improvements in clinical measures among both ChP1 and ChP2 groups (P <0.001). However, the adjunctive dose of vitamin C did not offer additional effect (P >0.05).
ChP is significantly associated with lower levels of plasma TAOC. The non-surgical periodontal therapy seems to reduce the oxidative stress during the periodontal inflammation. However, the use of adjunctive vitamin C still needs further investigation.
几项最近的研究表明，血浆总抗氧化能力（TAOC）似乎在慢性牙周炎（ChP）中受到损害。本研究旨在调查 ChP 患者的血浆 TAOC，并评估维生素 C 作为非手术牙周治疗辅助剂的效果。
研究人群包括 60 名受试者：30 名被诊断为 ChP 和 30 名匹配的对照。此外，ChP 组的患者被随机分为 ChP1（15 名患者接受非手术治疗，同时给予维生素 C 的辅助剂量）和 ChP2（15 名患者仅接受非手术牙周治疗）。在基线和治疗后 1 个月，通过 ABTS 测定法测量血浆 TAOC 水平。
ChP 患者的血浆 TAOC 水平明显低于对照组（P<0.001）。牙周治疗在 ChP1 和 ChP2 两组中均导致血浆 TAOC 增加和临床指标改善（P<0.001）。然而，辅助剂量的维生素 C 并没有提供额外的效果（P>0.05）。
ChP 与较低的血浆 TAOC 水平显著相关。非手术牙周治疗似乎可以减轻牙周炎症期间的氧化应激。然而，辅助使用维生素 C 仍需要进一步研究。
