Genomics and Biotecnology Program, Universidade Católica de Brasília, Brasília, DF, Brazil.
Mol Plant Pathol. 2003 Nov 1;4(6):517-30. doi: 10.1046/j.1364-3703.2003.00198.x.
SUMMARY The last decade has witnessed steady progress in deciphering the molecular basis of plant disease resistance and pathogen virulence. Although contributions have been made using many different plant and pathogen species, studies of the interactions between Arabidopsis thaliana and Pseudomonas syringae have yielded a particularly significant body of information. The present review focuses on recent findings regarding R gene products and the guard hypothesis, RAR1/SGT1 and other examples where protein processing activity is implicated in disease resistance or susceptibility, the use of microarray expression profiling to generate information and experimental leads, and important molecular- and genome-level discoveries regarding P. syringae effectors that mediate bacterial virulence. The development of the Arabidopsis-Pseudomonas model system is also reviewed briefly, and we close with a discussion of characteristics to consider when selecting other pathosystems as experimentally tractable models for future research.
摘要 在过去的十年中，人们在破译植物疾病抗性和病原体毒力的分子基础方面取得了稳步的进展。尽管使用了许多不同的植物和病原体物种进行了研究，但对拟南芥和丁香假单胞菌之间相互作用的研究提供了特别丰富的信息。本综述重点介绍了最近关于 R 基因产物和保护假说、RAR1/SGT1 以及其他涉及蛋白加工活性与疾病抗性或易感性的例子、使用微阵列表达谱生成信息和实验线索的研究，以及关于介导细菌毒性的丁香假单胞菌效应物的重要分子和基因组水平的发现。还简要回顾了拟南芥-丁香假单胞菌模型系统的发展，并在讨论中讨论了在选择其他病理系统作为未来研究的实验可处理模型时需要考虑的特征。
