Tsumura K, Kuwayama N, Iwai R, Kanbayashi T, Satoh H, Kubo M, Endo S
Department of Neurosurgery & Neurovascular Center, Kawasaki Saiwai Hospital; Kawasaki, Japan.
Interv Neuroradiol. 2006 Jan 20;12(Suppl 1):233-40. doi: 10.1177/15910199060120S143. Epub 2006 Jun 15.
Emergency revascularization of acute carotid artery occlusion is still controversial.We treated 15 patients (13 men and two women, mean age of 67.3 years) with acute atherosclerotic carotid occlusion by endovascular procedures and evaluated the usefulness of this treatment. All of the patients were evaluated with emergency MRI and MRA before treatment. Intracranial tandem arterial occlusion due to distal embolism was observed in nine patients, and contralateral carotid stenosis (> 70%) was observed in seven. The mean NIHSS score of the patients was 15.4 +/- 7.4 (mean +/- SD) before treatment. Treatment modality included local intraarterial fibrinolysis (LIF), percutaneous transluminal angioplasty (PTA), and carotid artery stenting (CAS). A protective balloon was successfully placed in the distal carotid artery through the plaque before recanalization in seven patients. Three patients were treated with LIF+PTA, five with PTA+CAS, six with LIF+PTA+CAS, and one with PTA only. Successful recanalization of the carotid artery was obtained in 14 of the 15 patients, and distal tandem middle cerebral artery occlusion was also successfully recanalized in eight of the nine patients. GOS was four or five in eight patients (good outcome group) and 1-3 in seven patients (poor outcome group). Mean NIHSS score of the 15 patients was (6.9 +/- 7.4) after treatment. Preoperative NIHSS score (10.3 +/- 7.4) in the good outcome group was significantly lower than that (21.3 +/- 5.4) in the poor outcome group. The protective balloon technique, PTA with stenting, seems to be useful for acute revascularization of urgent carotid occlusion. Simultaneous treatment of the intracranial tandem occlusive lesion is essential to achieve good clini-cal results. Patients with acute carotid occlusion with NIHSS scores of less than 16 could be good candidates for this advanced treatment.
急性颈动脉闭塞的急诊血管重建术仍存在争议。我们采用血管内介入手术治疗了15例急性动脉粥样硬化性颈动脉闭塞患者(13例男性,2例女性,平均年龄67.3岁),并评估了该治疗方法的有效性。所有患者在治疗前均接受了急诊MRI和MRA检查。9例患者观察到远端栓塞导致的颅内串联动脉闭塞,7例患者观察到对侧颈动脉狭窄(>70%)。治疗前患者的平均美国国立卫生研究院卒中量表(NIHSS)评分为15.4±7.4(平均值±标准差)。治疗方式包括局部动脉内溶栓(LIF)、经皮腔内血管成形术(PTA)和颈动脉支架置入术(CAS)。7例患者在再通前通过斑块成功地在远端颈动脉置入了保护球囊。3例患者接受LIF+PTA治疗,5例接受PTA+CAS治疗,6例接受LIF+PTA+CAS治疗,1例仅接受PTA治疗。15例患者中有14例成功实现了颈动脉再通,9例患者中有8例远端串联大脑中动脉闭塞也成功再通。8例患者的格拉斯哥预后评分(GOS)为4或5(良好预后组),7例患者为1 - 3(不良预后组)。15例患者治疗后的平均NIHSS评分为(6.9±7.4)。良好预后组术前NIHSS评分(10.3±7.4)显著低于不良预后组(21.3±5.4)。保护球囊技术、带支架的PTA似乎对紧急颈动脉闭塞的急性血管重建有用。同时治疗颅内串联闭塞性病变对于取得良好的临床效果至关重要。NIHSS评分小于16的急性颈动脉闭塞患者可能是这种先进治疗的良好候选者。