• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

临床转化中的干细胞治疗:缩小差距。

Clinical translation of stem cell therapies: a bridgeable gap.

机构信息

Andalusian Initiative for Advanced Therapies, Junta de Andalucía, Sevilla, Spain.

出版信息

Cell Stem Cell. 2010 Jun 4;6(6):508-12. doi: 10.1016/j.stem.2010.05.005.

DOI:10.1016/j.stem.2010.05.005
PMID:20569686
Abstract

Stem cell scientists trying to reach patients often lack the multidisciplinary skills needed to overcome complex regulatory barriers and may feel deterred from pursuing clinical implementation. In order to help bridge this gap, we offer a European perspective based on our hands-on experience at the Andalusian Initiative for Advanced Therapies.

摘要

干细胞科学家在试图接触患者时,往往缺乏克服复杂监管障碍所需的多学科技能,并且可能会因为担心无法实现临床转化而望而却步。为了帮助弥补这一差距,我们根据在安达卢西亚先进治疗倡议中的实践经验,提供了一个基于欧洲视角的方案。

相似文献

1
Clinical translation of stem cell therapies: a bridgeable gap.临床转化中的干细胞治疗:缩小差距。
Cell Stem Cell. 2010 Jun 4;6(6):508-12. doi: 10.1016/j.stem.2010.05.005.
2
Developing a case study model for successful translation of stem cell therapies.开发一个成功的干细胞疗法翻译案例研究模型。
Cell Stem Cell. 2010 Jun 4;6(6):513-6. doi: 10.1016/j.stem.2010.05.008.
3
Orphan products--pain relief for clinical development headaches.孤儿产品——缓解临床开发难题的良方。
Nat Biotechnol. 2002 Aug;20(8):780-4. doi: 10.1038/nbt0802-780.
4
Traveling across borders--the pitfalls of clinical trial regulation and stem cell exceptionalism.跨越国界——临床试验监管的陷阱与干细胞特殊论
Am J Bioeth. 2010 May;10(5):38-40. doi: 10.1080/15265161003754064.
5
Questions concerning the clinical translation of cell-based interventions under an innovation pathway.有关创新途径下基于细胞的干预措施的临床转化的问题。
J Law Med Ethics. 2012 Winter;40(4):945-50. doi: 10.1111/j.1748-720X.2012.00723.x.
6
[Orphan drugs: problem of public health and economic stakes].[罕见病药物:公共卫生问题与经济利益]
Therapie. 1996 Nov-Dec;51(6):647-53.
7
Orphan drug development: an economically viable strategy for biopharma R&D.孤儿药开发:生物制药研发的经济可行策略。
Drug Discov Today. 2012 Jul;17(13-14):660-4. doi: 10.1016/j.drudis.2012.02.005. Epub 2012 Feb 17.
8
Translating stem cell studies to the clinic for CNS repair: current state of the art and the need for a Rosetta stone.将干细胞研究转化为中枢神经系统修复的临床应用:现状与罗塞塔石的需求。
Neuron. 2011 May 26;70(4):597-613. doi: 10.1016/j.neuron.2011.05.007.
9
How can innovative forms of clinical research contribute to deliver affordable cancer care in an evolving health care environment?创新形式的临床研究如何能有助于在不断变化的医疗环境中提供负担得起的癌症护理?
Eur J Cancer. 2013 Sep;49(13):2777-83. doi: 10.1016/j.ejca.2013.05.016. Epub 2013 Jun 15.
10
Financing drug discovery for orphan diseases.为罕见病药物研发提供资金支持。
Drug Discov Today. 2014 May;19(5):533-8. doi: 10.1016/j.drudis.2013.11.009. Epub 2013 Nov 20.

引用本文的文献

1
Advanced Formulation Approaches for Emerging Therapeutic Technologies.新兴治疗技术的先进制剂方法
Handb Exp Pharmacol. 2024;284:343-365. doi: 10.1007/164_2023_695.
2
Education for the translation of Advanced Therapy Medicinal Products.先进治疗药品翻译培训
Front Med (Lausanne). 2023 Apr 4;10:1125892. doi: 10.3389/fmed.2023.1125892. eCollection 2023.
3
Compliance in Non-Clinical Development of Cell-, Gene-, and Tissue-Based Medicines: Good Practice for Better Therapies.细胞、基因和组织治疗药物非临床开发中的合规性:更好疗法的良好实践。
Stem Cells Transl Med. 2022 Aug 23;11(8):805-813. doi: 10.1093/stcltm/szac046.
4
Promoting the ethical use of safe and effective cell-based products: the Andalusian plan on regenerative medicine.促进安全有效细胞基产品的合理应用:安达卢西亚再生医学计划。
Cytotherapy. 2020 Dec;22(12):712-717. doi: 10.1016/j.jcyt.2020.07.007. Epub 2020 Aug 30.
5
Randomised, double-blind, placebo-controlled clinical trial for evaluating the efficacy of intracoronary injection of autologous bone marrow mononuclear cells in the improvement of the ventricular function in patients with idiopathic dilated myocardiopathy: a study protocol.随机、双盲、安慰剂对照临床试验评估自体骨髓单个核细胞冠状动脉内注射改善特发性扩张型心肌病患者心室功能的疗效:研究方案。
BMC Cardiovasc Disord. 2019 Aug 22;19(1):203. doi: 10.1186/s12872-019-1182-4.
6
Successful development and clinical translation of a novel anterior lamellar artificial cornea.成功开发并临床转化新型前板层人工角膜
J Tissue Eng Regen Med. 2019 Dec;13(12):2142-2154. doi: 10.1002/term.2951. Epub 2019 Oct 25.
7
Evaluation of the awareness of novel advanced therapies among family medicine residents in Spain.评估西班牙家庭医学住院医师对新型先进疗法的认知。
PLoS One. 2019 Apr 3;14(4):e0214950. doi: 10.1371/journal.pone.0214950. eCollection 2019.
8
Burn patient care lost in good manufacturing practices?烧伤患者护理在良好生产规范中缺失了吗?
Ann Burns Fire Disasters. 2016 Jun 30;29(2):111-115.
9
Clinical development of gene- and cell-based therapies: overview of the European landscape.基于基因和细胞疗法的临床开发:欧洲现状概述
Mol Ther Methods Clin Dev. 2016 Nov 30;3:16073. doi: 10.1038/mtm.2016.73. eCollection 2016.
10
Concepts in regenerative medicine: Past, present, and future in articular cartilage treatment.再生医学中的概念:关节软骨治疗的过去、现在与未来
J Clin Orthop Trauma. 2016 Jul-Sep;7(3):137-44. doi: 10.1016/j.jcot.2016.05.006. Epub 2016 Jun 15.