Anz Adam W, Bapat Asawari, Murrell William D
Andrews Research & Education Institute, Gulf Breeze, FL, USA.
Infohealth FZE, Dubai, United Arab Emirates.
J Clin Orthop Trauma. 2016 Jul-Sep;7(3):137-44. doi: 10.1016/j.jcot.2016.05.006. Epub 2016 Jun 15.
Regenerative medicine is emerging with great interest and hope from patients, industry, academia, and medical professionals. Cartilage regeneration, restoration, or repair is one of the prime targets that remains largely unsolved, and many believe that regenerative medicine can possibly deliver solutions that can be widely used to address the current gap(s) in treatment. In the United States, Europe, Australia, and India the regulation of regenerative based treatments has become a big debate. Although the rules and regulations remain unclear, clinicians that are interested should carry-on with the best available guidelines to ensure safety and compliance during delivery in clinical practice to avoid regulatory infraction. Many have made significant investment of time, resources, and facilities in recent years to provide new regenerative treatment options and advance medical care for patients. Instead of reinventing the wheel, it would be more efficient to adopt currently accepted standards and nomenclature borrowed from transplantation science, and cord blood storage industries. The purposes of this article are to provide some historical background to the field of regenerative medicine as it applies to cartilage, and how this field has developed. This will be followed by a separate discussion on regulatory oversight and input and how it has influenced access to care. Furthermore, we discuss current clinical techniques and progress, and ways to deliver these treatments to patients safely, effectively, and in a cost sensitive manner, concluding with an overview of some of the promising regenerative techniques specific to cartilage.
再生医学正带着患者、产业界、学术界和医学专业人士极大的兴趣与希望崭露头角。软骨再生、修复或修补是一个主要目标，在很大程度上仍未得到解决，许多人认为再生医学可能会提供可广泛用于填补当前治疗空白的解决方案。在美国、欧洲、澳大利亚和印度，基于再生的治疗的监管已成为一场激烈的辩论。尽管规则和条例仍不明确，但感兴趣的临床医生应遵循现有的最佳指南，以确保在临床实践中提供治疗时的安全性和合规性，避免违规行为。近年来，许多人在时间、资源和设施方面投入巨大，以提供新的再生治疗选择并为患者推进医疗护理。与其从头开始，采用目前从移植科学和脐带血储存行业借鉴的公认标准和术语会更有效率。本文的目的是提供再生医学领域应用于软骨方面的一些历史背景，以及该领域是如何发展的。随后将单独讨论监管监督和投入以及它如何影响医疗服务的可及性。此外，我们将讨论当前的临床技术和进展，以及以安全、有效且符合成本效益的方式向患者提供这些治疗的方法，最后概述一些特定于软骨的有前景的再生技术。
