Division of Endocrinology, University of Mississippi School of Medicine, Jackson, USA.
Am J Med. 2010 Jun;123(6):502-4. doi: 10.1016/j.amjmed.2009.12.023.
Subclinical thyroid disease, a term applied to patients with no or minimal thyroid-related symptoms with abnormal laboratory values, is diagnosed more frequently with the use of thyroid-stimulating hormone (TSH) screening and newer high-sensitivity assays. These are laboratory diagnoses, with subclinical hypothyroidism defined as an elevated TSH with a normal free thyroxine and triiodothyronine concentration, and subclinical hyperthyroidism as a subnormal TSH with normal free thyroxine and triiodothyronine levels. Although studies defining which patients require treatment are few, decisions should be individualized based upon laboratory values and symptoms. This article reviews the etiologies, diagnoses, treatments and indications, and monitoring of patients with subclinical thyroid disease.
亚临床甲状腺疾病是指应用促甲状腺激素（TSH）筛查和新型高敏检测方法诊断出的无或仅有轻微甲状腺相关症状但实验室值异常的患者。这些是实验室诊断，亚临床甲状腺功能减退症定义为 TSH 升高而游离甲状腺素和三碘甲状腺原氨酸浓度正常，亚临床甲状腺功能亢进症定义为 TSH 降低而游离甲状腺素和三碘甲状腺原氨酸水平正常。尽管定义哪些患者需要治疗的研究较少，但应根据实验室值和症状进行个体化决策。本文综述了亚临床甲状腺疾病患者的病因、诊断、治疗和适应证以及监测。
