Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, United States.
Neurobiol Aging. 2010 Aug;31(8):1326-39. doi: 10.1016/j.neurobiolaging.2010.04.006. Epub 2010 Jun 8.
Obesity is associated with lower brain volumes in cognitively normal elderly subjects, but no study has yet investigated the effects of obesity on brain structure in patients with mild cognitive impairment (MCI) or Alzheimer's disease (AD). To determine if higher body mass index (BMI) is associated with brain volume deficits in cognitively impaired elderly subjects, we analyzed brain magnetic resonance imaging (MRI) scans of 700 MCI or AD patients from 2 different cohorts: the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Cardiovascular Health Study-Cognition Study (CHS-CS). Tensor-based morphometry (TBM) was used to create 3-dimensional maps of regional tissue excess or deficits in subjects with MCI (ADNI, n = 399; CHS-CS, n = 77) and AD (ADNI, n = 188; CHS, n = 36). In both AD and MCI groups, higher body mass index was associated with brain volume deficits in frontal, temporal, parietal, and occipital lobes; the atrophic pattern was consistent in both ADNI and CHS populations. Cardiovascular risk factors, especially obesity, should be considered as influencing brain structure in those already afflicted by cognitive impairment and dementia.
肥胖与认知正常的老年患者的脑容量减少有关，但尚无研究调查肥胖对轻度认知障碍（MCI）或阿尔茨海默病（AD）患者脑结构的影响。为了确定较高的体重指数（BMI）是否与认知障碍的老年患者的脑容量缺陷有关，我们分析了来自 2 个不同队列的 700 名 MCI 或 AD 患者的脑磁共振成像（MRI）扫描：阿尔茨海默病神经影像学倡议（ADNI）和心血管健康研究-认知研究（CHS-CS）。基于张量的形态测量法（TBM）用于创建 MCI 患者（ADNI，n=399；CHS-CS，n=77）和 AD 患者（ADNI，n=188；CHS，n=36）的区域性组织过剩或缺陷的 3 维图谱。在 AD 和 MCI 组中，较高的体重指数与额叶、颞叶、顶叶和枕叶的脑容量减少有关；ADNI 和 CHS 人群中的萎缩模式一致。心血管危险因素，尤其是肥胖，应被视为已经患有认知障碍和痴呆的患者脑结构的影响因素。
