Cîmpeanu Radu-Cristian, Caragea Emilia-Mariana, Mustață Lorena-Maria, Forțofoiu Dragoș, Dragne Ioana-Gabriela, Alexa Raluca-Elena, Balta Anastasia, Ceasovschih Alexandr, Șorodoc Laurențiu, Săndulescu Larisa-Daniela
Doctoral School of University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Doctoral School of "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Int J Mol Sci. 2025 Mar 27;26(7):3081. doi: 10.3390/ijms26073081.
Obesity represents a complex, multifactorial syndrome that represents a high burden for public health systems worldwide. Serotonin is an important factor in feeding behavior and weight regulation and their interplay implies multiple mechanisms that could explain the correlation with obesity, so understanding these interconnections is essential for developing targeted therapeutic strategies. A systematic review of the literature was conducted using PubMed and Scopus databases, using articles published between 1 January 2015 and 1 December 2024, based on predefined inclusion and exclusion criteria. After the selection process, 22 studies were selected for detailed analysis, focusing on the role of serotonin in obesity. Serotonin significantly influences appetite control and energy homeostasis through multiples pathways, including insulin resistance, high-fat diets, gut microbiota, low-grade inflammation, interferences with tryptophan metabolism, psychiatric modifications, genetic alterations of serotonin receptors, serotonin implications in eating behavior, and neurohormonal regulation of appetite. This review highlights the multidimensional characteristics of the serotonin-obesity association, along with its significance in metabolic and psychiatric pathologies. In order to develop more efficient methods for managing obesity, future studies should concentrate on serotonergic regulation and complex management strategies involving the neurohormonal axis.
肥胖是一种复杂的多因素综合征，给全球公共卫生系统带来了沉重负担。血清素是进食行为和体重调节中的一个重要因素，其相互作用涉及多种机制，这些机制可以解释与肥胖的相关性，因此了解这些相互联系对于制定有针对性的治疗策略至关重要。基于预先定义的纳入和排除标准，使用PubMed和Scopus数据库对2015年1月1日至2024年12月1日期间发表的文章进行了文献系统综述。经过筛选过程，选择了22项研究进行详细分析，重点关注血清素在肥胖中的作用。血清素通过多种途径显著影响食欲控制和能量平衡，这些途径包括胰岛素抵抗、高脂饮食、肠道微生物群、低度炎症、色氨酸代谢干扰、精神状态改变、血清素受体的基因改变、血清素在饮食行为中的影响以及食欲的神经激素调节。本综述强调了血清素与肥胖关联的多维特征及其在代谢和精神疾病中的重要性。为了开发更有效的肥胖管理方法，未来的研究应集中在血清素能调节以及涉及神经激素轴的复杂管理策略上。
