School of Physics, University of Sydney, NSW, Australia.
Med Eng Phys. 2010 Sep;32(7):690-9. doi: 10.1016/j.medengphy.2010.04.011. Epub 2010 Jun 8.
New high performance polymers have been developed that challenge traditional encapsulation materials for permanent active medical implants. The gold standard for hermetic encapsulation for implants is a titanium enclosure which is sealed using laser welding. Polymers may be an alternative encapsulation material. Although many polymers are biocompatible, and permeability of polymers may be reduced to acceptable levels, the ability to create a hermetic join with an extended life remains the barrier to widespread acceptance of polymers for this application. This article provides an overview of the current techniques used for direct bonding of polymers, with a focus on thermoplastics. Thermal bonding methods are feasible, but some take too long and/or require two stage processing. Some methods are not suitable because of excessive heat load which may be delivered to sensitive components within the capsule. Laser welding is presented as the method of choice; however the establishment of suitable laser process parameters will require significant research.
已经开发出了新型高性能聚合物，它们挑战了用于永久性有源医疗植入物的传统封装材料。用于植入物的密封封装的金标准是使用激光焊接密封的钛外壳。聚合物可能是一种替代封装材料。尽管许多聚合物是生物相容的，并且聚合物的渗透性可以降低到可接受的水平，但能够用具有延长使用寿命的密封连接仍然是聚合物在该应用中被广泛接受的障碍。本文概述了用于聚合物直接键合的当前技术，重点是热塑性塑料。热键合方法是可行的，但有些方法耗时太长和/或需要两阶段处理。由于可能向封装内的敏感组件传递过多的热负荷，因此某些方法不适用。激光焊接被认为是首选方法；然而，合适的激光工艺参数的建立将需要大量的研究。
