阿尔茨海默病中迈内特基底核各局部亚区的细胞丢失与核肥大

Cell loss and nuclear hypertrophy in topographical subdivisions of the nucleus basalis of Meynert in Alzheimer's disease.

作者信息

Iraizoz I, de Lacalle S, Gonzalo L M

机构信息

Department of Anatomy, Faculty of Medicine, University of Navarra, Pamplona, Spain.

出版信息

Neuroscience. 1991;41(1):33-40. doi: 10.1016/0306-4522(91)90198-w.

DOI:10.1016/0306-4522(91)90198-w

PMID:2057064

Abstract

The nucleus basalis of Meynert was examined in six patients with Alzheimer's disease and five age-matched controls. A cytoarchitectonic study was followed by quantitative analysis of the population of neurons and by the determination of their nuclear area. Confirming previous neuropathological observations in Alzheimer's disease, a neuronal loss of 43% in the anterior, 25% in the intermediate and 30.5% in the posterior subdivisions of the nucleus basalis of Meynert was observed. Numerous surviving cells showed neurofibrillary tangles. In addition, we found that the nuclear area of the remaining nucleus basalis of Meynert neurons was significantly increased in all three subdivisions by at least 16%. The combined observation of cell loss and nuclear hypertrophy suggests that both regenerative and degenerative changes co-exist in the nucleus basalis in Alzheimer's disease.

摘要

对6例阿尔茨海默病患者和5例年龄匹配的对照者的迈内特基底核进行了检查。在细胞结构研究之后，对神经元群体进行了定量分析，并测定了它们的核面积。正如之前在阿尔茨海默病中所观察到的神经病理学结果一样，在迈内特基底核的前、中、后亚区分别观察到43%、25%和30.5%的神经元丢失。许多存活的细胞显示出神经原纤维缠结。此外，我们发现，在所有三个亚区中，迈内特基底核剩余神经元的核面积均显著增加，至少增加了16%。细胞丢失和核肥大的综合观察表明，在阿尔茨海默病中，迈内特基底核同时存在再生性和退行性变化。