Arendt T, Bigl V, Tennstedt A, Arendt A
Neurosci Lett. 1984 Jul 13;48(1):81-5. doi: 10.1016/0304-3940(84)90292-1.
In order to substantiate the hypothesis of a cholinergic matrix for neuritic plaque formation in Alzheimer's disease (AD), the relationship between the loss of cholinergic neurons in the basal forebrain and formation of neuritic plaques in the cerebral cortex was studied in 5 cases of neuropathologically verified AD. Quantitative evaluation of the number of neuritic plaques in the cerebral cortex as calculated from 6 areas showed a strong correlation with the loss of neurons in the nucleus basalis of Meynert (NbM). This finding indicates that changes in cortical cholinergic innervation which arise from the neurons of the NbM are an important feature in the pathogenesis of neuritic plaques.
为了证实阿尔茨海默病（AD）中神经炎性斑块形成的胆碱能基质假说，对5例经神经病理学证实的AD患者，研究了基底前脑胆碱能神经元缺失与大脑皮质神经炎性斑块形成之间的关系。通过计算6个区域得出的大脑皮质神经炎性斑块数量的定量评估显示，其与迈内特基底核（NbM）中神经元的缺失密切相关。这一发现表明，由NbM神经元引起的皮质胆碱能神经支配变化是神经炎性斑块发病机制中的一个重要特征。
