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哥廷根小型猪种群的遗传管理。

Genetic management of the Göttingen Minipig population.

作者信息

Simianer Henner, Köhn Friederike

机构信息

Georg-August Universität Göttingen, Animal Breeding and Genetics Group, Department of Animal Sciences, Albrecht-Thaer-Weg 3, D 37075 Göttingen, Germany.

出版信息

J Pharmacol Toxicol Methods. 2010 Nov-Dec;62(3):221-6. doi: 10.1016/j.vascn.2010.05.004. Epub 2010 Jun 4.

Abstract

The Göttingen Minipig is a laboratory animal of worldwide importance. The breed was developed in the 1960's at the University of Göttingen, Germany, using the founder breeds Minnesota Minipigs, Vietnamese Potbelly Pig and German Landrace. After the initial period under free range conditions the population was stocked under high hygienic standards. In 1992 an exclusive licence contract was made between Ellegaard Göttingen Minipigs ApS in Denmark and the University of Göttingen. Since 2002 the production and marketing of Göttingen Minipigs in the USA is managed by Marshall Farms, Inc. under licence from Ellegaard Göttingen Minipigs A/S. Today, there are three Danish, one American and one German population. The genetic management for all populations is provided by the University of Göttingen. The main focus is the maintenance and reduction of inbreeding and genetic drift, the maintenance of a high degree of uniformity and genetic progress in the main selection traits. The main selection trait in the past was the number of piglets born alive. By producing many piglets per sow and year, a fast genetic exchange of breeding animals could be achieved leading to a minimised inbreeding in the populations. To satisfy the market demands of a small and easy to handle minipig and to overcome the problem of an antagonistic relationship between litter size and body weight, the trait body weight reduction was included in the selection scheme using a restricted selection index. It is planned for the future to include temperament traits in the breeding scheme. Due to fast developments in genome-based breeding applications, these new methods can soon be implemented for an efficient control of genetic drift and inbreeding or even for genome-based selection.

摘要

哥廷根小型猪是一种具有全球重要性的实验动物。该品种于20世纪60年代在德国哥廷根大学培育而成,其基础品种包括明尼苏达小型猪、越南大肚猪和德国长白猪。在最初的放养阶段之后,猪群在高卫生标准下进行饲养。1992年,丹麦的埃勒高厄德哥廷根小型猪公司与哥廷根大学签订了独家许可合同。自2002年以来,美国的哥廷根小型猪生产和销售由马歇尔农场公司根据埃勒高厄德哥廷根小型猪公司的许可进行管理。如今,有三个丹麦种群、一个美国种群和一个德国种群。所有种群的遗传管理由哥廷根大学提供。主要重点是维持和减少近亲繁殖及遗传漂变,在主要选择性状上保持高度一致性和遗传进展。过去的主要选择性状是产活仔数。通过每头母猪每年产仔数多,可实现种畜的快速基因交换,从而使种群中的近亲繁殖降至最低。为满足市场对小型且易于管理的小型猪的需求,并克服产仔数与体重之间的拮抗关系问题,使用限制选择指数将体重降低性状纳入选择方案。计划在未来将性情性状纳入育种方案。由于基于基因组的育种应用发展迅速,这些新方法很快就能用于有效控制遗传漂变和近亲繁殖,甚至用于基于基因组的选择。

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