Karolinska Institute Department of Oncology-Pathology Cancer Center Karolinska, Stockholm, Sweden.
Hum Mutat. 2010 Sep;31(9):1020-5. doi: 10.1002/humu.21313.
Analysis of the literature reporting p53 mutations shows that 8% of report display typographical mistakes with a notable increase in recent years. These errors are sometimes isolated, but in some cases, they concern several or even all mutations described in a single article. Furthermore, some works report unusual profile of p53 mutations whose accuracy is difficult to assess. To handle these problems we have developed MUT-TP53 2.0, an accurate and powerful tool that will automatically handle p53 mutations and generate tables ready for publication that will lower the risk of typographical errors. Furthermore, using functional and statistical information issued from the UMD p53 database, it allows to assess the biological activity and the likelihood of every p53 mutant.
分析报告 p53 突变的文献表明，8%的文献存在印刷错误，且近年来显著增加。这些错误有时是孤立的，但在某些情况下，它们涉及单个文章中描述的多个甚至所有突变。此外，一些研究报告了不寻常的 p53 突变谱，其准确性难以评估。为了解决这些问题，我们开发了 MUT-TP53 2.0，这是一个准确而强大的工具，它将自动处理 p53 突变，并生成准备发表的表格，从而降低印刷错误的风险。此外，它还利用 UMD p53 数据库提供的功能和统计信息，评估每个 p53 突变体的生物活性和可能性。
