Dugald Baird Centre for Research on Women's Health, Aberdeen Maternity Hospital, Aberdeen, UK.
BJOG. 2010 Sep;117(10):1243-7. doi: 10.1111/j.1471-0528.2010.02641.x. Epub 2010 Jun 24.
To examine the risk of recurrence of stillbirth in a second pregnancy.
Retrospective cohort study.
Scotland, UK.
All women who delivered their first and second pregnancies in Scotland between 1981 and 2005.
All women delivering for the first time between 1981 and 2000 were linked to records of their second pregnancy using routinely collected data from the Scottish Morbidity Returns. Women who had an intrauterine death in their first pregnancy formed the exposed cohort, whereas those who had a live birth formed the unexposed cohort.
Stillbirth in a second pregnancy.
After adjusting for confounding factors, the odds of recurrence of stillbirth in a second pregnancy were found to be 1.94 (99% CI 1.29-2.92) compared with women who had had a live birth in their first pregnancy. Other factors associated with recurrence of stillbirth in a second pregnancy included placental abruption (adjusted OR 1.96; 99% CI 1.60-2.41), preterm delivery (adjusted OR 7.45; 99% CI 5.91-9.39) and low birthweight (adjusted OR 6.69; 99% CI 5.31-8.42). A Bayesian analysis using minimally informative normal priors found the risk of recurrence of stillbirth in a second pregnancy to be 1.59 (99% CI 1.10-2.33).
Women who have stillbirth in their first pregnancy have a higher risk of recurrence in their next pregnancy.
研究二胎中死胎复发的风险。
回顾性队列研究。
英国苏格兰。
1981 年至 2005 年期间在苏格兰首次分娩的所有女性。
1981 年至 2000 年间首次分娩的所有女性均通过苏格兰发病率报告中的常规收集数据与第二次妊娠的记录进行了关联。在第一次妊娠中发生宫内死亡的女性构成暴露队列，而在第一次妊娠中分娩活产的女性构成非暴露队列。
二胎中的死胎。
调整混杂因素后，与首次妊娠分娩活产的女性相比，二胎中死胎复发的几率为 1.94（99%CI 1.29-2.92）。与二胎中死胎复发相关的其他因素还包括胎盘早剥（调整后的比值比 1.96；99%CI 1.60-2.41）、早产（调整后的比值比 7.45；99%CI 5.91-9.39）和低出生体重（调整后的比值比 6.69；99%CI 5.31-8.42）。使用最小信息量正态先验的贝叶斯分析发现，二胎中死胎复发的风险为 1.59（99%CI 1.10-2.33）。
首次妊娠中发生死胎的女性，其下次妊娠中死胎复发的风险更高。
