Department of Neuropaediatrics, University Children's Hospital, Inselspital, Berne, Switzerland.
Dev Med Child Neurol. 2010 Dec;52(12):1145-50. doi: 10.1111/j.1469-8749.2010.03722.x.
AIMo describe the characteristics of paediatric cerebral sinus venous thrombosis (CSVT) in Switzerland.
data on clinical features, neuroimaging, risk factors, and treatment were collected for all children in Switzerland younger than 16 years of age who had CSVT between January 2000 and December 2008. A follow-up examination and a cognitive assessment were performed (mean follow-up period 26mo). Differences between neonates and children (patients older than 28d) were assessed and predictors of outcome were determined.
twenty-one neonates (14 males, seven females; mean age 9d, SD 8d) and 44 children (30 males, 14 females; mean age 8y 7mo, SD 4y 5mo) were reported. The incidence of paediatric CSVT in Switzerland was 0.558 per 100000 per year. In neonates, the deep venous system was more often involved and parenchymal injuries were more common. The strongest predictor of poor outcome was neonatal age (odds ratio 17.8, 95% confidence interval 0.847-372.353). Most children showed global cognitive abilities within the normal range, but impairments in single cognitive subdomains were frequent.
paediatric CSVT is rare. Its outcome is poor in neonates. Most children have good neurological outcomes, but some patients have individual neuropsychological impairments.
描述瑞士小儿脑窦静脉血栓形成（CSVT）的特征。
收集了 2000 年 1 月至 2008 年 12 月期间瑞士所有年龄小于 16 岁的 CSVT 患儿的临床特征、神经影像学、危险因素和治疗的数据。对所有患儿进行了随访检查和认知评估（平均随访时间为 26 个月）。评估了新生儿与儿童（>28d 患儿）之间的差异，并确定了预后的预测因素。
报告了 21 例新生儿（14 例男性，7 例女性；平均年龄 9d，SD 8d）和 44 例儿童（30 例男性，14 例女性；平均年龄 8 岁 7 个月，SD 4 岁 5 个月）。瑞士小儿 CSVT 的发病率为每年每 100000 人 0.558 例。在新生儿中，深静脉系统更常受累，实质损伤更常见。不良预后的最强预测因素是新生儿年龄（比值比 17.8，95%置信区间 0.847-372.353）。大多数儿童的整体认知能力在正常范围内，但单个性认知领域的损伤较为常见。
小儿 CSVT 罕见。新生儿预后较差。大多数儿童神经功能结局良好，但部分患儿存在个体神经心理损伤。
