Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
Division of Neurocritical Care and Emergency Neurology, Yale School of Medicine, New Haven, CT, USA.
Neurotherapeutics. 2023 Apr;20(3):705-711. doi: 10.1007/s13311-023-01377-1. Epub 2023 Apr 21.
Stroke is a leading cause of morbidity and mortality worldwide; a serious complication of ischemic stroke is hemorrhagic transformation. Current treatment of acute ischemic stroke includes endovascular thrombectomy and thrombolytic therapy. Both of these treatment options are linked with increased risks of hemorrhagic conversion. The diagnosis and timely management of patients with hemorrhagic conversion is critically important to patient outcomes. This review aims to discuss hemorrhagic conversion of acute ischemic stroke including discussion of the pathophysiology, review of risk factors, imaging considerations, and treatment of patients with hemorrhagic conversion.
中风是全球发病率和死亡率的主要原因;缺血性中风的严重并发症是出血性转化。目前急性缺血性中风的治疗包括血管内血栓切除术和溶栓治疗。这两种治疗选择都与出血性转化的风险增加有关。对出血性转化患者的诊断和及时治疗对患者的预后至关重要。本文旨在讨论急性缺血性中风的出血性转化，包括发病机制的讨论、危险因素的回顾、影像学考虑因素和出血性转化患者的治疗。
