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本文引用的文献

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Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men.体质指数和代谢综合征对中年男性心血管疾病和死亡风险的影响。
Circulation. 2010 Jan 19;121(2):230-6. doi: 10.1161/CIRCULATIONAHA.109.887521. Epub 2009 Dec 28.
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Are metabolically normal but obese individuals at lower risk for all-cause mortality?代谢正常但肥胖的个体是否全因死亡率风险较低？
Diabetes Care. 2009 Dec;32(12):2297-9. doi: 10.2337/dc09-0574. Epub 2009 Sep 3.
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Effects of exercise modality on insulin resistance and functional limitation in older adults: a randomized controlled trial.运动方式对老年人胰岛素抵抗和功能受限的影响：一项随机对照试验
Arch Intern Med. 2009 Jan 26;169(2):122-31. doi: 10.1001/archinternmed.2008.558.
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Metabolically healthy but obese women: effect of an energy-restricted diet.代谢健康但肥胖的女性：能量限制饮食的影响。
Diabetologia. 2008 Sep;51(9):1752-4. doi: 10.1007/s00125-008-1038-4. Epub 2008 May 27.
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Weight loss effect on inflammation and LDL oxidation in metabolically healthy but obese (MHO) individuals: low inflammation and LDL oxidation in MHO women.体重减轻对代谢健康但肥胖（MHO）个体炎症和低密度脂蛋白氧化的影响：MHO女性炎症和低密度脂蛋白氧化程度较低
Int J Obes (Lond). 2006 Oct;30(10):1529-34. doi: 10.1038/sj.ijo.0803304. Epub 2006 Mar 21.
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Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement.代谢综合征的诊断与管理：美国心脏协会/美国国立心肺血液研究所科学声明
Circulation. 2005 Oct 25;112(17):2735-52. doi: 10.1161/CIRCULATIONAHA.105.169404. Epub 2005 Sep 12.
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Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial.运动诱导女性肥胖和胰岛素抵抗的降低：一项随机对照试验。
Obes Res. 2004 May;12(5):789-98. doi: 10.1038/oby.2004.95.
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Determination of endothelial function and early atherosclerotic changes in healthy obese women.健康肥胖女性内皮功能及早期动脉粥样硬化改变的测定
Diabetes Nutr Metab. 2003 Jun;16(3):176-81.
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Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial.男性通过饮食诱导减重或运动诱导减重后肥胖及相关合并症的减少。一项随机对照试验。
Ann Intern Med. 2000 Jul 18;133(2):92-103. doi: 10.7326/0003-4819-133-2-200007180-00008.
10
Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health.《成人超重与肥胖的识别、评估及治疗临床指南——证据报告》。美国国立卫生研究院。
Obes Res. 1998 Sep;6 Suppl 2:51S-209S.

代谢健康肥胖男性和女性的体重变化的影响。

Effects of weight loss among metabolically healthy obese men and women.

机构信息

School of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.

出版信息

Diabetes Care. 2010 Sep;33(9):1957-9. doi: 10.2337/dc10-0547. Epub 2010 Jun 23.

DOI:10.2337/dc10-0547
PMID:20573755
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2928342/
Abstract

OBJECTIVE

Weight loss among metabolically healthy obese (MHO) individuals may be unnecessary or result in elevated cardio-metabolic risk. We studied the effects of exercise- or diet-induced weight loss on cardio-metabolic risk among MHO and metabolically abnormal obese (MAO) adults.

RESEARCH DESIGN AND METHODS

Participants were 63 MHO and 43 MAO adults who took part in 3 to 6 months of exercise- or diet-induced weight loss intervention. Changes in anthropometry, adipose tissue distribution, and cardio-metabolic risk factors were assessed.

RESULTS

Body weight, waist circumference, and total abdominal and visceral adipose tissue were reduced in all subjects (P < 0.05). Improvements in insulin sensitivity were observed in MHO and MAO men and women (P < 0.05), but were greater in the MAO individuals (P < 0.05). Fasting insulin was the only other cardio-metabolic improvement among MHO individuals (P < 0.05).

CONCLUSIONS

Lifestyle-induced weight loss among MHO subjects is associated with a reduction in total and abdominal obesity and improvement in selected cardio-metabolic risk factors.

摘要

目的

代谢健康型肥胖（MHO）个体的体重减轻可能是不必要的，或者会导致心血管代谢风险升高。我们研究了运动或饮食诱导的体重减轻对 MHO 和代谢异常肥胖（MAO）成年人的心血管代谢风险的影响。

研究设计和方法

参与者为 63 名 MHO 和 43 名 MAO 成年人，他们参加了 3 至 6 个月的运动或饮食诱导的体重减轻干预。评估了人体测量学、脂肪组织分布和心血管代谢危险因素的变化。

结果

所有受试者的体重、腰围以及腹部和内脏总脂肪组织均减少（P<0.05）。MHO 和 MAO 男女的胰岛素敏感性均有所改善（P<0.05），但 MAO 个体的改善更为明显（P<0.05）。MHO 个体中唯一其他改善的心血管代谢因素是空腹胰岛素（P<0.05）。

结论

MHO 受试者的生活方式诱导的体重减轻与总肥胖和腹部肥胖的减少以及某些心血管代谢风险因素的改善有关。