St. Vincent's Hospital Melbourne, Australia.
Adv Anat Pathol. 2010 Jul;17(4):251-61. doi: 10.1097/PAP.0b013e3181e4abdb.
Ocular adnexal lymphomas comprise 1% to 2% of all non-Hodgkin lymphomas and about 8% of extranodal lymphomas. They are a heterogeneous group of malignancies, the majority of which are primary extranodal lymphoma with most (up to 80%) of the marginal zone of mucosa associated lymphoid tissue type (MALT lymphoma). This review will encompass the incidence, histology, immunophenotyping, recent advances in molecular and cytogenetics, clinical features including outcome, and prognostic factors. The association with Chlamydia psittaci and the very recently recognized occurrence in the context of IgG4-related sclerosing disease will be discussed. Finally, traditional (surgery, radiotherapy, chemotherapy) and newer forms of therapy (immunotherapy and radioimmunotherapy) will be reviewed.
眼附属器淋巴瘤占所有非霍奇金淋巴瘤的 1%至 2%，占结外淋巴瘤的 8%左右。它们是一组异质性的恶性肿瘤，大多数为原发性结外淋巴瘤，其中大多数（高达 80%）为黏膜相关淋巴组织型边缘区淋巴瘤（MALT 淋巴瘤）。这篇综述将包括发病率、组织学、免疫表型、分子和细胞遗传学的最新进展、包括预后在内的临床特征，以及预后因素。将讨论与鹦鹉热衣原体的相关性以及最近在 IgG4 相关硬化性疾病背景下发现的相关性。最后，将回顾传统的（手术、放疗、化疗）和较新的治疗形式（免疫疗法和放射免疫疗法）。
