Malhotra O P, Salam S R
Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
Postgrad Med J. 1991 Jan;67(783):87-9. doi: 10.1136/pgmj.67.783.87.
A patient with chronic myeloid leukaemia, having two unusual features, is described. He had absence of splenomegaly and marked periodic fluctuations of leucocyte counts, occurring spontaneously, in the initial phase of the disease. The latter finding suggests that, at least in some patients with chronic myeloid leukaemia, negative feed back control mechanism(s), possibly exerted by colony stimulating factor, may be retained which may have therapeutic implications.
本文描述了一名患有慢性粒细胞白血病的患者,该患者具有两个不寻常的特征。在疾病的初始阶段,他没有脾肿大,且白细胞计数出现明显的周期性自发波动。后一发现表明,至少在一些慢性粒细胞白血病患者中,可能由集落刺激因子发挥作用的负反馈控制机制可能仍然存在,这可能具有治疗意义。