Chikkappa G, Borner G, Burlington H, Chanana A D, Cronkite E P, Ohl S, Pavelec M, Robertson J S
Blood. 1976 Jun;47(6):1023-30.
A patient with chronic myelocytic leukemia had a cyclic oscillation of blood neutrophils, eosinophils, monocytes, platelets, normoblasts, and reticulocytes but not of lymphocytes. The cycle interval was 53--69 days. Except for reticulocytes all other cells cycled with neutrophils. Plasma colony-stimulating factor (CSF) oscillated out of phase with neutrophils, suggesting that granulocytopoiesis is regulated through CSF by a feed-back mechanism. Plasma erythropoiesis-stimulating factor (ESF) also oscillated. ESF crests preceded or coincided with reticulocyte crests, indicating that the ESF elevation may have been responsible for the reticulocyte peaks. The relationship between neutrophils and reticulocytes and their oscillations with plasma CSF and ESF suggests that there is a common stem cell which differentiates along one cell line or the other depending upon the balance of regulatory stimuli. The fraction of blood neutrophilic precursors (myeloblasts, promyelocytes, and myelocytes) in DNA synthesis fluctuated with neutrophil level. The calculated generation time was shorter at the crests than at the troughs of the neutrophil cycles. This finding suggested that the rate of proliferation of the neutrophils changed periodically. This observation, along with a periodic increase in differentiation of the stem cell toward the neutrophilic cells, is the probable explanation of oscillation of the neutrophil count in the blood.
一名慢性粒细胞白血病患者的血液中性粒细胞、嗜酸性粒细胞、单核细胞、血小板、幼红细胞和网织红细胞出现周期性波动，但淋巴细胞未出现。周期间隔为53 - 69天。除网织红细胞外，所有其他细胞均与中性粒细胞同步循环。血浆集落刺激因子（CSF）与中性粒细胞呈不同相位波动，提示粒细胞生成是通过CSF经反馈机制调节的。血浆红细胞生成刺激因子（ESF）也有波动。ESF高峰先于或与网织红细胞高峰同时出现，表明ESF升高可能是网织红细胞峰值的原因。中性粒细胞与网织红细胞之间的关系以及它们与血浆CSF和ESF的波动表明，存在一种共同的干细胞，它根据调节刺激的平衡沿着一种或另一种细胞系分化。血液中性粒细胞前体（原粒细胞、早幼粒细胞和中幼粒细胞）中处于DNA合成期的比例随中性粒细胞水平波动。计算得出的生成时间在中性粒细胞周期的高峰比低谷时短。这一发现提示中性粒细胞的增殖速率呈周期性变化。这一观察结果，连同干细胞向嗜中性细胞分化的周期性增加，可能是血液中中性粒细胞计数波动的原因。
