Sirsi Shashank, Borden Mark
Department of Chemical Engineering, Columbia University, 500 W 120 ST, New York, NY 10027.
Bubble Sci Eng Technol. 2009 Nov;1(1-2):3-17. doi: 10.1179/175889709X446507.
Over the last decade, there has been significant progress towards the development of microbubbles as theranostics for a wide variety of biomedical applications. The unique ability of microbubbles to respond to ultrasound makes them useful agents for contrast ultrasound imaging, molecular imaging, and targeted drug and gene delivery. The general composition of a microbubble is a gas core stabilized by a shell comprised of proteins, lipids or polymers. Each type of microbubble has its own unique advantages and can be tailored for specialized functions. In this review, different microbubbles compositions and physiochemical properties are discussed in the context of current progress towards developing novel constructs for biomedical applications, with specific emphasis on molecular imaging and targeted drug/gene delivery.
在过去十年中，微泡作为用于广泛生物医学应用的诊疗试剂，其开发取得了重大进展。微泡对超声作出反应的独特能力使其成为超声造影成像、分子成像以及靶向药物和基因递送的有用试剂。微泡的一般组成是由蛋白质、脂质或聚合物构成的壳层所稳定的气体核心。每种类型的微泡都有其独特的优势，并且可以针对特定功能进行定制。在本综述中，将在开发用于生物医学应用的新型构建体的当前进展背景下，讨论不同的微泡组成和理化性质，特别强调分子成像和靶向药物/基因递送。
