Zou Qingqin, Deng Xiao, Wang Zhihao, Guo Shifang, Zong Yujin, Qin Dui, Wan Mingxi
Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710115, PR China.
Chongqing Engineering Research Center of Medical Electronics and Information Technology, Department of Biomedical Engineering, School of Life Health Information Science and Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, PR China.
Ultrason Sonochem. 2025 Aug;119:107405. doi: 10.1016/j.ultsonch.2025.107405. Epub 2025 May 29.
The polymer-coated microbubble stimulated by focused acoustic vortex has great potential in enhancing the targeted drug delivery, but the dynamic behaviors of the microbubble in the focal cross-section of focused acoustic vortex requires further investigation. A mathematical model, which accounts for the acoustic radiation force, changes in the instantaneous acoustic field and the effects of shell properties, is developed to investigate the translational motions and radial oscillations of a polymer-coated microbubble excited by a focused acoustic vortex. Results show that in the focal cross-section, the microbubble in all cases moves in a direction consistent with the change of acoustic phase. The microbubble located at a relatively small initial distance from the focus moves toward the focus. However, once the initial distance exceeds a certain threshold, the microbubble moves away from the focus. Furthermore, a larger topological charge of the focused acoustic vortex results in a larger initial distance threshold. In regard to radial oscillations, the oscillation amplitude of microbubble decreases with an increase in the driving cycle due to its translational motion. Moreover, increasing the initial external radius of the microbubble or the velocity amplitude of the n sectorial transducer enhances the translational motions and radial oscillations of the microbubble. Conversely, these dynamic behaviors are suppressed by increasing the topological charge, viscosity of the surrounding medium, shell viscoelasticity and thickness. This work comprehensively investigates the polymer-coated microbubble dynamics in the focal cross-section of focused acoustic vortex. It provides preliminary insights into the mechanism of combining focused acoustic vortex technology with polymer-coated microbubble for targeted drug delivery, which may contribute to optimization of experimental parameters settings.
聚焦声涡激发的聚合物包被微泡在增强靶向药物递送方面具有巨大潜力，但微泡在聚焦声涡焦点横截面上的动力学行为仍需进一步研究。本文建立了一个考虑声辐射力、瞬态声场变化和壳层性质影响的数学模型，以研究聚焦声涡激发的聚合物包被微泡的平动和径向振荡。结果表明，在焦点横截面上，所有情况下微泡的运动方向都与声相位变化一致。位于离焦点相对较小初始距离处的微泡向焦点移动。然而，一旦初始距离超过某个阈值，微泡就会远离焦点。此外，聚焦声涡的拓扑电荷越大，初始距离阈值就越大。关于径向振荡，由于微泡的平动，其振荡幅度随驱动周期的增加而减小。此外，增加微泡的初始外半径或扇形换能器的速度幅度会增强微泡的平动和径向振荡。相反，增加拓扑电荷、周围介质的粘度、壳层粘弹性和厚度会抑制这些动力学行为。这项工作全面研究了聚合物包被微泡在聚焦声涡焦点横截面上的动力学。它为聚焦声涡技术与聚合物包被微泡结合用于靶向药物递送的机制提供了初步见解，这可能有助于优化实验参数设置。
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