Cross-linked peptoid-based dimerization inhibitors of HIV-1 protease.
作者信息
Lee Song-Gil, Chmielewski Jean
机构信息
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA.
出版信息
Chembiochem. 2010 Jul 26;11(11):1513-6. doi: 10.1002/cbic.201000248.
Abstract
摘要
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本文引用的文献
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Targeting protein-protein interactions by rational design: mimicry of protein surfaces.通过合理设计靶向蛋白质-蛋白质相互作用：蛋白质表面的模拟
J R Soc Interface. 2006 Apr 22;3(7):215-33. doi: 10.1098/rsif.2006.0115.
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Examples of peptide-peptoid hybrid serine protease inhibitors based on the trypsin inhibitor SFTI-1 with complete protease resistance at the P1-P1' reactive site.基于胰蛋白酶抑制剂SFTI-1的肽-类肽杂合丝氨酸蛋白酶抑制剂的实例，在P1-P1'反应位点具有完全的蛋白酶抗性。
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Crucial amides for dimerization inhibitors of HIV-1 protease.
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Small-Molecule Inhibitors of HIV-1 Protease Dimerization Derived from Cross-Linked Interfacial Peptides This work was supported by NIH (GM52739) and NSF (9457372-CHE).源自交联界面肽的HIV-1蛋白酶二聚化小分子抑制剂 本研究受美国国立卫生研究院（GM52739）和美国国家科学基金会（9457372-CHE）资助。
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