Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, United States of America; Institute for NanoBioTechnology, The Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, United States of America.
Department of Surgery, The Johns Hopkins University School of Medicine, United States of America.
J Control Release. 2022 Aug;348:1028-1049. doi: 10.1016/j.jconrel.2022.06.037. Epub 2022 Jul 6.
Peptides and peptide-based materials have an increasing role in the treatment of viral infections through their use as active pharmaceutical ingredients, targeting moieties, excipients, carriers, or structural components in drug delivery systems. The discovery of peptide-based therapeutic compounds, coupled with the development of new stabilization and formulation strategies, has led to a resurgence of antiviral peptide therapeutics over the past two decades. The ability of peptides to bind cell receptors and to facilitate membrane penetration and subsequent intracellular trafficking enables their use in various antiviral systems for improved targeting efficiency and treatment efficacy. Importantly, the self-assembly of peptides into well-defined nanostructures provides a vast library of discrete constructs and supramolecular biomaterials for systemic and local delivery of antiviral agents. We review here the recent progress in exploiting the therapeutic, biological, and self-assembling potential of peptides, peptide conjugates, and their supramolecular assemblies in treating human viral infections, with an emphasis on the treatment strategies for Human Immunodeficiency Virus (HIV).
肽和基于肽的材料在治疗病毒感染方面的作用越来越大，它们可以作为活性药物成分、靶向部分、赋形剂、载体或药物传递系统中的结构成分。在过去的二十年中，基于肽的治疗化合物的发现，加上新的稳定化和配方策略的发展，使得抗病毒肽治疗药物重新受到关注。肽能够结合细胞受体并促进膜穿透和随后的细胞内运输，这使其能够用于各种抗病毒系统，以提高靶向效率和治疗效果。重要的是，肽自组装成具有明确定义的纳米结构，为系统和局部递抗病毒药物提供了大量离散构建体和超分子生物材料库。本文综述了利用肽、肽缀合物及其超分子组装体的治疗、生物学和自组装潜力来治疗人类病毒感染的最新进展，重点介绍了人类免疫缺陷病毒 (HIV) 的治疗策略。
