Department of Emergency Medicine, Oregon Health & Science University, Portland, OR 97239-3098, USA.
Clin Toxicol (Phila). 2010 Jul;48(6):533-8. doi: 10.3109/15563650.2010.492526.
Ingestion of concentrated hydrogen peroxide (H(2)O(2)) has been associated with venous and arterial gas embolic events, hemorrhagic gastritis, gastrointestinal bleeding, shock, and death. Although H(2)O(2) is generally considered a benign ingestion in low concentrations, case reports have described serious toxicity following high concentration exposures. Hyperbaric oxygen (HBO) has been used with success in managing patients suffering from gas embolism with and without manifestations of ischemia.
Poison center records were searched from July 1999 to January 2010 for patients with H(2)O(2) exposure and HBO treatment. Cases were reviewed for the concentration of H(2)O(2), symptoms, CT scan findings of portal gas embolism, HBO treatment, and outcome. RESULTS; Eleven cases of portal gas embolism were found. Ages ranged from 4 to 89 years. All but one ingestion was accidental in nature. In 10 cases 35% H(2)O(2) was ingested and in 1 case 12% H(2)O(2) was ingested. All abdominal CT scans demonstrated portal venous gas embolism in all cases. Hyperbaric treatment was successful in completely resolving all portal venous gas bubbles in nine patients (80%) and nearly resolving them in two others. Ten patients were able to be discharged home within 1 day, and one patient had a 3.5-day length of stay.
HBO was successful in resolving portal venous gas embolism from accidental concentrated H(2)O(2) ingestions.
摄入高浓度过氧化氢（H₂O₂）与静脉和动脉气体栓塞事件、出血性胃炎、胃肠道出血、休克和死亡有关。尽管 H₂O₂在低浓度下通常被认为是良性摄入物，但病例报告描述了高浓度暴露后出现严重毒性的情况。高压氧（HBO）已成功用于治疗有和没有缺血表现的气体栓塞患者。
从 1999 年 7 月至 2010 年 1 月，在毒物中心的记录中搜索了过氧化氢暴露和 HBO 治疗的患者。对病例进行了回顾，以了解 H₂O₂浓度、症状、门静脉气体栓塞的 CT 扫描结果、HBO 治疗和结果。
发现 11 例门静脉气体栓塞病例。年龄范围为 4 至 89 岁。除 1 例外，所有摄入均为意外性质。在 10 例中，摄入了 35%的 H₂O₂，在 1 例中，摄入了 12%的 H₂O₂。所有腹部 CT 扫描均显示门静脉气体栓塞。高压治疗成功地完全消除了 9 例患者（80%）的所有门静脉气体泡，并几乎消除了另外 2 例患者的气体泡。10 名患者在 1 天内能够出院，1 名患者住院 3.5 天。
HBO 成功地解决了意外摄入高浓度 H₂O₂引起的门静脉气体栓塞。
