Program of Molecular and Clinical Pharmacology ICBM, Faculty of Medicine, University of Chile, Santiago, Chile.
Addict Biol. 1999 Oct;4(4):443-8. doi: 10.1080/13556219971434.
The effects of low to moderate doses of ethanol on spontaneous locomotor activity were studied in the selectively bred high-ethanol drinking (UChB) and the low-ethanol drinking (UChA) strain of rats. Alcohol-naive rats had food and water available ad libitum, although food was removed 24 hours before and during activity testing. After an injection of c.15 M NaCl or ethanol (0.25-1.0 g/kg), spontaneous locomotor activity was monitored every 5 minutes for 20 minutes in an open field apparatus. The UChB rats exhibited increased locomotor activity after doses of 0.25 and 0.50 g/kg of ethanol, while UChA rats failed to show increased locomotor activity at any ethanol dose. Moreover, the UChA rats appeared to be more sensitive to the sedating effects of 1.0 g/kg of ethanol than the UChB rats. These differences were not the result of different brain-blood alcohol levels. Ethanol intakes by the UChB and UChA rats determined at the conclusion of activity testing averaged 5.0 ± 0.5 and 1.9 ± 0.4 g/kg/day, respectively. The data suggest that ethanol-induced locomotor stimulation may be associated with ethanol preference and that hyperactivity may be an expression of the positive reinforcing effect of ethanol in UChB rats.
本研究旨在探讨低至中等剂量乙醇对选择性培育的高乙醇摄入（UChB）和低乙醇摄入（UChA）大鼠自发活动的影响。在活动测试前 24 小时和测试期间，酒精新手大鼠可自由获取食物和水。在注射约 15 M NaCl 或乙醇（0.25-1.0 g/kg）后，在开放场装置中每 5 分钟监测一次 20 分钟的自发运动活动。UChB 大鼠在摄入 0.25 和 0.50 g/kg 乙醇后表现出运动活动增加，而 UChA 大鼠在任何乙醇剂量下均未表现出运动活动增加。此外，UChA 大鼠似乎比 UChB 大鼠对 1.0 g/kg 乙醇的镇静作用更为敏感。这些差异不是由于大脑血液酒精水平不同造成的。活动测试结束时 UChB 和 UChA 大鼠的乙醇摄入量平均为 5.0 ± 0.5 和 1.9 ± 0.4 g/kg/天。这些数据表明，乙醇引起的运动刺激可能与乙醇偏好有关，而过度活跃可能是 UChB 大鼠中乙醇正强化作用的表现。
