低剂量乙醇对 UChB 和 UChA 大鼠自发运动活性的影响。

Effect of low doses of ethanol on spontaneous locomotor activity in UChB and UChA rats.

机构信息

Program of Molecular and Clinical Pharmacology ICBM, Faculty of Medicine, University of Chile, Santiago, Chile.

出版信息

Addict Biol. 1999 Oct;4(4):443-8. doi: 10.1080/13556219971434.

DOI:10.1080/13556219971434

PMID:20575813

Abstract

The effects of low to moderate doses of ethanol on spontaneous locomotor activity were studied in the selectively bred high-ethanol drinking (UChB) and the low-ethanol drinking (UChA) strain of rats. Alcohol-naive rats had food and water available ad libitum, although food was removed 24 hours before and during activity testing. After an injection of c.15 M NaCl or ethanol (0.25-1.0 g/kg), spontaneous locomotor activity was monitored every 5 minutes for 20 minutes in an open field apparatus. The UChB rats exhibited increased locomotor activity after doses of 0.25 and 0.50 g/kg of ethanol, while UChA rats failed to show increased locomotor activity at any ethanol dose. Moreover, the UChA rats appeared to be more sensitive to the sedating effects of 1.0 g/kg of ethanol than the UChB rats. These differences were not the result of different brain-blood alcohol levels. Ethanol intakes by the UChB and UChA rats determined at the conclusion of activity testing averaged 5.0 ± 0.5 and 1.9 ± 0.4 g/kg/day, respectively. The data suggest that ethanol-induced locomotor stimulation may be associated with ethanol preference and that hyperactivity may be an expression of the positive reinforcing effect of ethanol in UChB rats.

摘要

本研究旨在探讨低至中等剂量乙醇对选择性培育的高乙醇摄入（UChB）和低乙醇摄入（UChA）大鼠自发活动的影响。在活动测试前 24 小时和测试期间，酒精新手大鼠可自由获取食物和水。在注射约 15 M NaCl 或乙醇（0.25-1.0 g/kg）后，在开放场装置中每 5 分钟监测一次 20 分钟的自发运动活动。UChB 大鼠在摄入 0.25 和 0.50 g/kg 乙醇后表现出运动活动增加，而 UChA 大鼠在任何乙醇剂量下均未表现出运动活动增加。此外，UChA 大鼠似乎比 UChB 大鼠对 1.0 g/kg 乙醇的镇静作用更为敏感。这些差异不是由于大脑血液酒精水平不同造成的。活动测试结束时 UChB 和 UChA 大鼠的乙醇摄入量平均为 5.0 ± 0.5 和 1.9 ± 0.4 g/kg/天。这些数据表明，乙醇引起的运动刺激可能与乙醇偏好有关，而过度活跃可能是 UChB 大鼠中乙醇正强化作用的表现。