Department of Surgery, Division of Vascular Surgery, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30 001, 9700 RB Groningen, The Netherlands.
Eur J Vasc Endovasc Surg. 2010 Sep;40(3):348-54. doi: 10.1016/j.ejvs.2010.05.016. Epub 2010 Jun 23.
To investigate the diagnostic accuracy of fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) compared with computed tomography (CT) scanning and added value of fused FDG-PET-CT in diagnosing vascular prosthetic graft infection.
Prospective cohort study with retrospective analysis.
Twenty five patients with clinically suspected vascular prosthetic infection underwent CT and FDG-PET scanning.
Two nuclear medicine physicians assessed the FDG-PET scans; all CT scans were assessed by two radiologists. Fused FDG-PET/CT were judged by the radiologist and the nuclear medicine physician. The concordance between CT and FDG-PET and the inter-observer agreement between the different readers were investigated.
Fifteen patients had a proven infection by culture. Single FDG-PET had the best results (sensitivity 93%, specificity 70%, positive predictive value 82% and negative predictive value 88%). For CT, these values were 56%, 57%, 60% and 58%, respectively. Fused CT and FDG-PET imaging also showed high sensitivity and specificity rates and high positive and negative values. Inter-observer agreement for FDG-PET analysis was excellent (kappa = 1.00) and moderate for CT and fused FDG-PET-CT analysis (0.63 and 0.66, respectively).
FDG-PET scanning showed a better diagnostic accuracy than CT for the detection of vascular prosthetic infection. This study suggests that FDG-PET provides a useful tool in the work-up for diagnosis of vascular prosthetic graft infection.
研究氟代-2-脱氧-D-葡萄糖正电子发射断层扫描（FDG-PET）与计算机断层扫描（CT）扫描相比的诊断准确性，以及融合 FDG-PET-CT 在诊断血管假体感染中的附加价值。
前瞻性队列研究结合回顾性分析。
25 例临床疑似血管假体感染的患者接受了 CT 和 FDG-PET 扫描。
两名核医学医师评估了 FDG-PET 扫描；两名放射科医师评估了所有 CT 扫描。FDG-PET/CT 融合由放射科医师和核医学医师判断。研究了 CT 和 FDG-PET 之间的一致性以及不同读者之间的观察者间一致性。
15 例患者经培养证实存在感染。单 FDG-PET 的结果最佳（灵敏度 93%，特异性 70%，阳性预测值 82%和阴性预测值 88%）。对于 CT，这些值分别为 56%、57%、60%和 58%。融合 CT 和 FDG-PET 成像也显示出较高的灵敏度和特异性以及较高的阳性和阴性值。FDG-PET 分析的观察者间一致性极好（kappa=1.00），而 CT 和融合 FDG-PET-CT 分析的观察者间一致性为中度（0.63 和 0.66）。
FDG-PET 扫描在检测血管假体感染方面比 CT 具有更高的诊断准确性。本研究表明，FDG-PET 为血管假体感染的诊断提供了有用的工具。
