Petri H, Urquhart J
Department of Epidemiology, University of Limburg, Maastricht, The Netherlands.
Stat Med. 1991 Apr;10(4):577-81. doi: 10.1002/sim.4780100409.
Channeling is a form of allocation bias, where drugs with similar therapeutic indications are prescribed to groups of patients with prognostic differences. Claimed advantages of a new drug may channel it to patients with special pre-existing morbidity, with the consequence that disease states can be incorrectly attributed to use of the drug. For the study of adverse drug reactions, large databases supply information on co-medication and morbidity of patients. For diseases with a stepped-care approach, the drug history of patients, as available from some databases, can show channeling of drugs to patients with markers of relatively severe disease.
药物分流是一种分配偏倚形式，即具有相似治疗适应症的药物被开给具有预后差异的患者群体。新药所谓的优势可能会使其被用于有特殊既往疾病的患者，结果是疾病状态可能会被错误地归因于该药物的使用。对于药物不良反应的研究，大型数据库提供了患者合并用药和疾病情况的信息。对于采用分级护理方法治疗的疾病，一些数据库中提供的患者用药史可能显示药物被分流到患有相对严重疾病标志物的患者。
