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经巩膜二极管激光睫状体光凝术治疗视力良好的患者。

Transscleral diode laser cycloablation in patients with good vision.

机构信息

Tennent Institute of Ophthalmology, Gartnavel Hospital, Great Western Road, Glasgow G12 0YN, UK.

出版信息

Br J Ophthalmol. 2010 Sep;94(9):1180-3. doi: 10.1136/bjo.2008.145565. Epub 2010 Jun 24.

Abstract

PURPOSE

To investigate the effect of diode laser cyclophotocoagulation for glaucoma on central visual function in patients with good visual acuity (VA).

PATIENTS AND METHODS

Patients with preoperative VA 20/60 or better who had undergone cyclodiode treatment according to a standard protocol were evaluated retrospectively. The primary outcome variable was a recorded loss of two or more Snellen lines of best corrected VA during follow-up. Successful intraocular pressure (IOP) control was defined as being between 6 and 21 mmHg inclusive without oral acetazolamide or other glaucoma surgery.

RESULTS

49 eyes of 43 patients with a median pretreatment acuity of 20/30 were included (range 20/16-20/60). After a mean duration of follow-up of 5.0 years, median VA was 20/60 with a line loss of two or more recorded in 15 eyes (30.6%) (mean survival time 7.7 years). 67.3% (33/49) retained VA 20/60 or better, but VA deteriorated by one Snellen line or more in 31 (63.2%), and in 16.3% (8/49), final VA was <20/200. In cases experiencing a two-line loss in acuity, the main causes were glaucoma progression (nine cases) and macula oedema (four cases). Visual loss was unrelated to total treatment dose (mean 99.7 J), initial acuity or initial IOP level. IOP was controlled at final follow-up in 39/49 (79.6%) with no cases of hypotony.

CONCLUSIONS

Most of these eyes with difficult to manage glaucoma retained their good VA over long-term follow-up after undergoing diode laser cyclophotocoagulation. The proportion losing two Snellen lines is in line with that reported after trabeculectomy or tube surgery. These results suggest a possible role for the use of transscleral cyclodiode in selected eyes with significant visual potential. Further controlled prospective studies are required to better define this role.

摘要

目的

研究二极管激光睫状体光凝术治疗视力良好(VA)的青光眼对中心视觉功能的影响。

方法

回顾性评估根据标准方案接受二极管激光睫状体光凝术治疗的术前 VA 为 20/60 或更好的患者。主要观察变量是在随访过程中记录到最佳矫正 VA 丧失两个或更多 Snellen 线。成功的眼内压(IOP)控制定义为 6 至 21mmHg 之间,不包括口服乙酰唑胺或其他青光眼手术。

结果

43 例患者的 49 只眼纳入研究,中位数预处理视力为 20/30(范围为 20/16-20/60)。平均随访 5.0 年后,中位数 VA 为 20/60,15 只眼(30.6%)记录到两个或更多 Snellen 线的视力丧失(平均生存时间 7.7 年)。67.3%(33/49)保留了 20/60 或更好的 VA,但 31 只眼(63.2%)的 VA 恶化了一个 Snellen 线或更多,16.3%(8/49)的最终 VA <20/200。在视力丧失两线的病例中,主要原因是青光眼进展(9 例)和黄斑水肿(4 例)。视力丧失与总治疗剂量(平均 99.7J)、初始视力或初始 IOP 水平无关。在 49 例中有 39 例(79.6%)在最终随访时 IOP 得到控制,无低眼压病例。

结论

这些接受二极管激光睫状体光凝术治疗的难以控制的青光眼眼中,大多数在长期随访中保留了良好的 VA。丧失两个 Snellen 线的比例与小梁切除术或管手术报告的比例一致。这些结果表明,在具有显著视力潜力的选定眼中,使用经巩膜二极管可能具有一定的作用。需要进一步进行对照前瞻性研究以更好地确定这一作用。

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